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Anterior Eye Research at Aston

Members of the Aston anterior eye research team

The aim of our research is to better understand the anatomy and physiology of the anterior eye, through and allowing the design and evaluation of enhanced devices.

 Research Expertise: key areas

Intraocular lenses; Cataract and Refractive Surgery; Contact Lenses; Dry Eye; Ocular Allergy; Ocular Biometry, Corneal Biomechanics and Ophthalmic Imaging and Technology

Our team has a broad range of skills and experience and comprises:

  • Academics: Prof James Wolffsohn; Dr Leon Davies; Dr Shehzad Naroo; Dr Amy Sheppard; Dr Janis Orr; Dr Mark Dunne; Dr Tom Drew; Dr Antonio Fratini and Dr Olivia Hunt

  • Ophthalmologists: Prof Sunil Shah (Midland Eye; Birmingham and Midlands Eye Centre), Mr Joseph Abbott (Birmingham Children’s Hospital), Mr Maged Nessim and Dr Sai Kolli (Queen Elizabeth Hospital Birmingham)

  • Research Fellows: Dr Alec Kingsnorth; Dr Ben Coldrick; Dr Debbie Laughton; Dr Paramdeep Bilkhu; Dr Raquel Gil-Cazorla; Dr Emma Berrow; Dr Fabrizio Zeri

  • Research postgraduates: Madara Zvirgzdina; Said Karimzad; Maana Aujla; Laika Essa; Una Whitcomb; Rubinder Panesar; Nguyen Damiano; Dr Wan Haslina Wan Abdul Halim; Dr Meena Basta; Neelam Patel; Parminder Randhawa; Richa Saigal

  • Master Engineer: Mr. Graham Davies

  • Visiting ResearchersProf Martin Rubinstein; Prof Michel Guillon; Prof Christine Purslow; Prof Edward Mallen; Dr Graeme Young; Dr Lee Hall; Dr Heiko Pult; Kevin Blake  

Anterior Eye image 1




 Intraocular Lenses, Cataract and Refractive Surgery

Our intraocular lens (IOL), cataract and refractive surgery research involves clinical trials (of accommodating, multifocal and violet and blue-blocking IOL designs and femtosecond laser); development of enhanced methodology to assess depth of focus, contrast sensitivity and dysphotopsia; use of advanced instrumentation to evaluate objective accommodation, ocular aberrations and measure ocular biometry, and the development of a validated questionnaire regarding the restoration of near visual function in presbyopic eyes

  • Recent publications in the field of IOLs, cataract and refractive surgery include:Osipov V, Doskolovich L, Bezus E, Drew T, Zhou K, Sawalha K, Swadener G, Wolffsohn JS. Application of nanoimprinting technique for fabrication of trifocal diffractive lens with sine-like radial profile. Journal of Biomedical Optics. In press 
  • Berrow,E Wolffsohn,J Bilkhu,P Dhallu,S Naroo,A Shah,S. (2014) Visual performance of a new bi-aspheric, segmented, asymmetric multifocal intraocular lens. Journal of Refractive Surgery 30, 584-588.
  • Wolffsohn,JS Jinabhai,AN Kingsnorth,A Sheppard,AL Naroo,SA Shah,S Buckhurst,P Hall,LA Young,G. (2013) Exploring the optimum step size for defocus curves. Journal of Cataract and Refractive surgery. 39, 873-880. 
  • Sheppard,AL Shah,S Bhatt,U Bhogal,G Wolffsohn,JS. (2013) Visual outcomes and subjective experience following bilateral implantation of a new diffractive trifocal intraocular lens. Journal of Cataract and Refractive Surgery. 39, 343-349Dhallu,S 
  • Sheppard,AL Wolffsohn,JS (2014) Evaluating the effect of splitting cylindrical power on improving patient tolerance to toric lens misalignment. Contact Lens and Anterior Eye. 37, 191-195.Bhogal-Bhamra,GK Wolffsohn,JS Sheppard,AL Naroo,SA Shah,S Buckhurst,P (2015) The effect of dilation on toric intraocular lens aligning and centring. Advances in ophthalmology and Visual Science 2, 00028. 
  • Schmickler,S Palomino Bautista,C Goes,F Shah,S Wolffsohn,JS (2013) Clinical evaluation of a multifocal aspheric diffractive intraocular lens. British Journal of Ophthalmology. 97, 1560-1564.

Anterior Eye image 2

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Contact Lenses

The team's varied contact lens research activities include objective image analysis and grading of anterior eye features; unique non-invasive measurement of corneal oxygen consumptionthermographic and objective analysis of the tear film; clinical trials of monovision and multifocal designs; evaluation and development of novel materials and the impact on the tear film, and ocular surface.

Recent publications in the field of contact lenses include:

  • Belda-Salmerón L, Drew T, Hall L, Wolffsohn JS. (2015) Objective analysis of contact lens fit. Contact Lens and Anterior Eye. In press
  • Wolffsohn,JS Tharoo,A Lakhlani,N (2015) Optimal time following fluorescein instillation to evaluate rigid gas pearmeable contact lens fit. Contact Lens and Anterior Eye In press
  • Wolffsohn,JS van der Worp,E de Brabander,J. (2013) Consensus on recording of gas permeable contact lens fit. Contact Lens & Anterior Eye. 36, 299-303.
  • Best,N Drury,L Wolffsohn,JS (2013) Predicting success with silicone-hydrogel contact lenses in new wearers. Contact Lens and Anterior Eye. 36, 232-237.
  • Hall,L Hunt,C Young,G Wolffsohn,JS (2013) Factors affecting corneoscleral topography. Investigative Ophthalmology and Visual Science. 54, 3691-3701.
  • Wolffsohn,JS Drew,T Dhallu,S Sheppard,A Hofmann,GJ Prince,M (2013) Impact of soft contact lens edge design and midperipheral lens shape on the epithelium and its indentation with lens mobility. Investigative Ophthalmology and Visual Science. 54, 1690-1696.
Anterior Eye image 3



Dry Eyes and Ocular Allergy

The team is a partner in the European Union Horizon 2020 funded European Dry Eye Network (EDEN) involving the training of 10 postgraduate students, the development of new instrumentationtreatment evaluation and an in-vitro tissue model.

 

Recent publications in the field of dry eyes and ocular allergy include:

  • Bilkhu,PS Wolffsohn,JS Tang,GW Naroo,S. (2014) Management of dry eye in UK pharmacies Contact Lens & Anterior Eye 37, 382-387.
  • Bilkhu,PS Naroo,SA Wolffsohn,JS (2014) Randomised masked clinical trial of the MGDRx EyeBag for the treatment of meibomian gland dysfunction related evaporative dry eye. British Journal of Ophthalmology 98, 1707-1711.
  • Bilkhu,PS Naroo,SA Wolffsohn,JSW (2014) Effect of a commercially available wam compress on eyelid temperature and tear film in healthy eyes. Optometry and Vision Science. 91, 163-170.
  • Papas,EB Ciolino,J Jacobs,D Miller,W Pult,H Sahin,A Srinivasan,S Tauber,J Wolffsohn,J Nelson,JD + (2013) The TFOS international workshop on contact lens discomfort: report of the management and therapy subcommittee. Investigative Ophthalmology and Visual Science. 54, TFOS183-203.
  • Bilkhu,PS Wolffsohn,JS Naroo,SA Robertson,L Kennedy,R (2013) Effectiveness of Non-Pharmacological Treatments for Acute Seasonal Allergic Conjunctivitis. Ophthalmology. 121, 72-78.
  • Bilkhu,P Wolffsohn,JS Taylor,D Gibson,E Hirani,B Naroo,SA. (2013) The management of ocular allergy in community pharmacies in the United Kingdom. International Journal of Clinical Pharmacy. 35, 190-4.DOI: 10.1007/s11096-012-9742-z

Instrumentation

The team incorporates collaboration between mechanical, electrical and biomedical engineers as well as healthcare professionals. They have spun-out a business Aston EyeCare Ltd to commercialise their diagnostic systems, tablet and smartphone mobile app supported testsportable instrumentation, software solutions and technical consultancy 

Recent publications on instrumentation include:

  • Wolffsohn JS, Drew T. (2015) Usability of Prostaglandin Monotherapy Eye Droppers. British Journal of Ophthalmology. In press.
  • Kingsnorth,A Wolffsohn,JS (2014) Mobile app reading speed test. British Journal of Ophthalmology. In press
  • Wolffsohn,JS Drew,T Sulley,A (2014) Conjunctival UV autofluorescence – prevalence and risk factors. Contact Lens and Anterior Eye 37, 427-430.
  • Mandal,P Berrow,EJ Naroo,SA Wolffsohn,JS Uthoff,D Holland,D Shah, S (2014). Validity and repeatability of the Aladdin ocular biometer. British Journal of Ophthalmology. 98, 256-258.
  • Bhatt,UK Sheppard,AL Shah,S Dua,HS Mihashi,T Yamaguchi,T Wolffsohn,JS. (2013) Design and validity of a miniaturised open-field aberrometer. Journal of Cataract and Refractive surgery. 39, 36-40.
Anterior Eye image 4

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