Restoring blood flow to the heart following a heart attack can leave patients with ventricular fibrillation, a dangerous heart rhythm which puts people at greater risk of sudden cardiac death.
Previous research has shown carbon monoxide, which is produced naturally in heart cells, can guard against ventricular fibrillation however the mechanism behind why this happens was previously unknown.
Scientists at Aston Medical School at Aston University, and Peking University in China, have found carbon monoxide works by blocking the channels that carry potassium into heart cells – an essential process required to reset the cells before their next heartbeat.
When someone has an arrhythmia their heart beats more erratically. By blocking the potassium channels researchers were able to slow down the heart rate and counteract the dangerous effects of the abnormal rhythm.
Findings from the research project, funded by the British Heart Foundation (BHF) and Medical Research Council could be used to explore new life-saving treatments for patients with ventricular fibrillation.
Professor Asif Ahmed, Pro-Vice-Chancellor for Health and Professor of Vascular Biology at Aston University, said: “Our latest research highlights that compounds that deliver low levels of carbon monoxide can block specific ion channels in the heart muscle to allow the muscle time to contract properly and forcefully in a coordinated fashion. This discovery provides a new potential therapeutic target.
“In the future, we hope to explore how this can be of direct benefit to patients but more fundamental mechanistic research is still needed and we look to charities like the BHF for support for the on-going collaboration between Peking University and Aston Medical School. "
Professor Peter Weissberg, Medical Director at the BHF, which helped fund the research, said: “This exciting science explains how the carbon monoxide molecule, which is produced by our heart cells during a heart attack, can protect hearts from potentially fatal disturbances of heart rhythm. This opens the way for research to develop drugs that mimic this effect and that could one day protect patients who are at risk of life threatening arrhythmias."
For further media information contact Alex Earnshaw Aston University Communications on 0121 204 4549 or firstname.lastname@example.org
Notes to editors
Issued in response to: Carbon monoxide inhibits inward rectifier potassium channels in cardiomyocytes by Shenghui Liang et al Peking University. Nature Communications. DOI: 10.1038/ncomms5676 Published online August 14, 2014