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Professor Peter A. Lambert

 

Professor of Microbial Chemistry 

School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: p.a.lambert@aston.ac.uk
telephone: +44 (0) 121 204 3976
fax: +44 (0) 121 204 3892

Research Theme

Chronic and Communicable Conditions

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA) 

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Career History

  • 2011-date Professor of Microbial Chemistry, Aston University
  • 2005-2011 Professor of Microbiology, Aston University
  • 1998-2005 Reader in Microbiology, Aston University
  • 1990-98 Senior Lecturer in Microbiology, Aston University
  • 1990 DSc., Loughborough University
  • 1980-90 Lecturer in Microbiology, Aston University
  • 1977-80 Section Head, Microbial Biochemistry, Glaxo Group Research, Greenford
  • 1974-77 Research Fellow, University of Newcastle upon Tyne (with Sir James Baddiley)
  • 1970-74 PhD., CNAA, London
  • 1966-70 BSc., Chemistry, Loughborough University
  • 1966-70 Diploma of Industrial Studies, Loughborough University

Research Interests

  • Infectious diseases, their diagnosis and treatment
  • Molecular typing and epidemiology of infectious diseases
  • Microbial pathogenicity, virulence factors, adhesion and colonisation, resistance to host defences
  • Antibiotics, mechanisms of action and resistance
  • Structure, function, properties and biosynthesis of microbial cell walls and membranes 

PubMed search for publications

 Recent publications with links (2008-14)

Genotypic and Antimicrobial Characterisation of Propionibacterium acnes Isolates from Surgically Excised Lumbar Disc Herniations. Rollason J, McDowell A, Albert HB, Barnard E, Worthington T, Hilton AC, Vernallis A, Patrick S, Elliott T, Lambert P. Biomed Res Int. 2013;2013:530382.

Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? Albert HB, Lambert P, Rollason J, Sorensen JS, Worthington T, Pedersen MB, Nørgaard HS, Vernallis A, Busch F, Manniche C, Elliott T. Eur Spine J. 2013 22(4):690-6.

Answer to the Letter to the Editor of Zafar Ahmad et al. concerning "Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized controlled trial of efficacy" by Albert HB et al., Eur Spine J (2013) 22:697-707. Lambert P, Albert HB. Eur Spine J. 2013 Oct;22(10):2346-7.

The N-Terminus of CD14 Acts to Bind Apoptotic Cells and Confers Rapid-Tethering Capabilities on Non-Myeloid Cells. Thomas L, Bielemeier A, Lambert PA, Darveau RP, Marshall LJ, Devitt A. PLoS One. 2013 8(7):e70691.

Indwelling catheters and medical implants with FXIIIa inhibitors: A novel approach to the treatment of catheter and medical device-related infections. Daneshpour N, Collighan R, Perrie Y, Lambert P, Rathbone D, Lowry D, Griffin M. Eur J Pharm Biopharm. 2012 S0939-6411.

The antimicrobial efficacy of copper alloy furnishing in the clinical environment: a crossover study. Karpanen TJ, Casey AL, Lambert PA, Cookson BD, Nightingale P, Miruszenko L, Elliott TS. Infect Control Hosp Epidemiol. 2012 33 3-9.

Lecture Notes: Medical Microbiology and Infection. Tom Elliott, Anna Casey, Peter Lambert, Jonathan Sandoe. 2011 John Wiley & Sons, ISBN-10: 1-4443-3465-4.

Propionibacterium acnes: infection beyond the skin. Perry A, Lambert PA. Expert Rev Anti Infect Ther. 2011 9 1149-56.

A comparative study to evaluate surface microbial contamination associated with copper-containing and stainless steel pens used by nurses in the critical care unit. Casey AL, Karpanen TJ, Adams D, Lambert PA, Nightingale P, Miruszenko L, Elliott TS. Am J Infect Control. 2011 39 52-4.

Antimicrobial activity of a chlorhexidine intravascular catheter site gel dressing. Karpanen TJ, Casey AL, Conway BR, Lambert PA, Elliott TS. J Antimicrob Chemother. 2011 66 1777-84.

A Novel Multilocus Sequence Typing Scheme for the Opportunistic Pathogen Propionibacterium acnes and Characterisation of Type I Cell Surface-Associated Antigens. McDowell A, Gao A, Barnard E, Fink C, Murray PI, Dowson CG, Nagy I, Lambert PA, Patrick S. Microbiology. 2011 157 1990-2003.

Genetic characterisation of clinical isolates of Clostridium difficile using an optimised RAPD protocol and PCR ribotyping reveals strain diversity between two tertiary referral Trusts in the West Midlands, UK. Green LM, Worthington T, Hilton AC, Lambert PA. J Med Microbiol. 2011 60 1287-91.

Histidine acts as a co-germinant with glycine and taurocholate for Clostridium difficile spores. Wheeldon L, Worthington T, Lambert P. J Appl Microbiol. 2011 Jan 24 PMID: 21261795.

Proteomic analysis of the anti-inflammatory action of minocycline. Dunston CR, Griffiths HR, Lambert PA, Staddon S, Vernallis AB. Proteomics. 2011 11 42-51.

Methicillin-resistant Staphylococcus aureus bacteremia: epidemiology, outcome, and laboratory characteristics in a tertiary referral center in the UK. Lewis T, Chaudhry R, Nightingale P, Lambert P, Das I. Int J Infect Dis. 2011 15 131-5.

Enhanced chlorhexidine skin penetration with eucalyptus oil. Karpanen TJ, Conway BR, Worthington T, Hilton AC, Elliott TS, Lambert PA. BMC Infect Dis. 2010 10 278.

Peptidoglycan derived from S. epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells. Robertson J, Lang S, Lambert PA, Martin PE. Biochem J. 2010 432 133-43.

Serum procalcitonin, interleukin-6, soluble intercellular adhesin molecule-1 and IgG to short-chain exocellular lipoteichoic acid as predictors of infection in total joint prosthesis revision. Worthington T, Dunlop D, Casey A, Lambert P, Luscombe J, Elliott T. Br J Biomed Sci. 2010 67 71-6.

Phenotypic characterisation of Clostridium difficile reveals lack of extracellular virulence factor production and significant differences in antibiogram profiles. Green LM, Worthington T, Hilton AC, Lambert PA. Int J Antimicrob Agents. 2010 35 305-6.

Casey AL, Adams D, Karpanen TJ, Lambert PA, Cookson BD, Nightingale P, Miruszenko L, Shillam R, Christian P, Elliott TS. Role of copper in reducing hospital environment contamination. J Hosp Infect. 2010 74 72-7.

Surgical site infection: are we using the right skin preparation? Elliott T, Lambert P. Br J Hosp Med (Lond). 2009 70 552-3.

Preoperative skin preparation: a historical perspective. Crosby CT, TSJ E, Lambert PA, Adams D. Br J Hosp Med (Lond). 2009 70 579-82.

Hendry ER, Worthington T, Conway BR, Lambert PA. Antimicrobial efficacy of eucalyptus oil and 1,8-cineole alone and in combination with chlorhexidine digluconate against microorganisms grown in planktonic and biofilm cultures. J Antimicrob Chemother. 2009 64 1219-25.

Venkateswaran RV, Dronavalli V, Lambert PA, Steeds RP, Wilson IC, Thompson RD, Mascaro JG, Bonser RS.The proinflammatory environment in potential heart and lung donors: prevalence and impact of donor management and hormonal therapy. Transplantation. 2009 88 582-8.

Mehmi M, Marshall LJ, Lambert PA, Smith JC.Evaluation of disinfecting procedures for aseptic transfer in hospital pharmacy departments. PDA J Pharm Sci Technol. 2009 63 123-38.

Karpanen TJ, Worthington T, Conway BR, Hilton AC, Elliott TS, Lambert PA. Permeation of chlorhexidine from alcoholic and aqueous solutions within excised human skin. Antimicrob Agents Chemother. 2009 53 1717-19. 

Wheeldon LJ, Worthington T, Hilton AC, Elliott TS, Lambert PA.Physical and chemical factors influencing the germination of Clostridium difficile spores. J Appl Microbiol. 2009 105 2223-30.

Woodford N, Wareham DW; UK Antibacterial Antisense Study Group.Tackling antibiotic resistance: a dose of common antisepsis? J Antimicrob Chemother. 2009 63 225-9.

Smith AR, Lambert PA.Antimicrobial action of N-(n-dodecyl)diethanolamine on Escherichia coli: effects on enzymes and growing cultures. J Appl Microbiol. 2008 105 2161-8.

Rollason J, Bastin L, Hilton AC, Pillay DG, Worthington T, McKeon C, De P, Burrows K, Lambert PA. Epidemiology of community-acquired meticillin-resistant Staphylococcus aureus obtained from the UK West Midlands region. J Hosp Infect. 2008 70 314-20.

Small H, Adams D, Casey AL, Crosby CT, Lambert PA, Elliott T. Efficacy of adding 2% (w/v) chlorhexidine gluconate to 70% (v/v) isopropyl alcohol for skin disinfection prior to peripheral venous cannulation. Infect Control Hosp Epidemiol. 2008 29 963-5.

Karpanen TJ, Worthington T, Hendry ER, Conway BR, Lambert PA. Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis. J Antimicrob Chemother. 2008 62 1031-6.

Karpanen TJ, Worthington T, Conway BR, Hilton AC, Elliott TS, Lambert PA. Penetration of chlorhexidine into human skin. Antimicrob Agents Chemother. 2008 52 3633-6.  

Wheeldon LJ, Worthington T, Lambert PA, Hilton AC, Lowden CJ, Elliott TS. Antimicrobial efficacy of copper surfaces against spores and vegetative cells of Clostridium difficile: the germination theory. J Antimicrob Chemother. 2008 62 522-5.

Wheeldon LJ, Worthington T, Hilton AC, Lambert PA, Elliott TS. Sporicidal activity of two disinfectants against Clostridium difficile spores. Br J Nurs. 2008 17 316-20.

Costello C, Karpanen T, Lambert PA, Mistry P, Parker KJ, Rathbone DL, Ren J, Wheeldon L, Worthington T. Thiosemicarbazones active against Clostridium difficile. Bioorg Med Chem Lett. 2008 18 1708-11.  

McDowell A, Perry AL, Lambert PA, Patrick S. A new phylogenetic group of Propionibacterium acnes. J Med Microbiol. 2008 57 218-24.

Dias IH, Marshall L, Lambert PA, Chapple IL, Matthews JB, Griffiths HR. Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant. Infect Immun. 2008 76 317-23.

Prof Peter Lambert / Aston University / last updated 21st January 2014

Employable Graduates; Exploitable Research