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Dr Andrew Ingham

Lecturer Pharmaceutics/ Drug Delivery
Dr A.Ingham
A.Ingham,

 

 PharmacyChronic and Communicable ConditionsAston Research Centre for Healthy Ageing (ARCHA)Member of the Pharmacy and Biology Teaching Programmes, Pharmaceutical; freeze drying , transdermal, and small molecule interaction research. 

School of Life and Health Sciences, Aston University, MB 341C - Aston Triangle, Birmingham B4 7ET, UK, Telephone: +44 (0) 121 204 3913, Inghamaj@aston.ac.uk

Teaching Activity on the MPharm Programme

Pharmacy group
Module co-ordinator for PHMCT2, PH3704. 
Oxidise

Area of expertise/ Research interests

Pharmaceutical freeze drying provides solid state storage conditions for many small molecule and protein therapeutics. 

  • Reteplase Recombinant injections
  • Diltiazem
  • Immune globulin (human) for injection
  • Interferon Beta -1b
  • Acetazolamide injection

Formulation scientists using freeze drying are typically seeking low temperature processing of materials to avoid the decomposition and loss in activity involved in many high temperature drying techniques.

Typical pharmaceutical process optimisation taking place in our laboratory involves:

  • Controlled cooling of the initial formulation (which is typically a solution or suspension)
    • Crystallisation of problematic molecules
  • Treatment of the frozen solid
    • Storage conditions for frozen materials - hold times
    • Annealing of frozen materials
  • Sublimation of the solid solvent
  • Desorption of moisture within the dried product
  • Sealing of the product environment either under vacuum or ‘backfilled’ with an inert gas

Both process optimisation and formulation optimisation cannot be underestimated with powdered materials varying greatly if processed improperly.

Research focuses on optimisation of the freeze drying environment as well as the full range of solution and powder technologies required to best characterise the freeze dried material and final presentation.

Career History 

Dr Ingham qualified as a pharmacist in 2000 gaining his doctorate from the London School of Pharmacy (University College London) in 2004 for his work in freeze drying technology. His research lead to a position in a consultancy directly tailored to freeze drying (lyophilisation) and its associated powder technology.  

As a pharmacist he has occupied a variety of posts including contractual positions for hospital, community and the police.

Along side his continued work into the characterisation of freeze-dried material, a cycling  interest encompasses sporting supplementation and nutraceuticals in the powdered form.

Year/ Employer Partners.
2008- date
Aston University
2007- 2008
2006- 2007

Membership of Professional Bodies

  • The Royal Pharmaceutical Society of Great Britain

Recent Publications  

  • Burnett,A Thielmann,F Ward,K and Ingham,A (2006) “Impact of Protein Concentration on the Moisture-Induced Phase Transitions of Protein-Sugar Mixtures” American BiotechnologyLab, 24(4), 25-27

  • Ingham,A Banks,D Ward,K (2005) “Foundation of the Lyophilization characterisation database” Biopharma Technology LTD.

  • Ingham,A Alpar H O (2003) "Freeze dry layer coating for stabilisation” PharmSci 5(4) W5121

  • Ingham,A Alpar H O (2002) “Protection of liposome’s from lyophilization induced aggregation” J Pharm Pharmacol 54(s) 104.

 

 

The Laboratory

This photosynth (you may need a plugin) is of one of the experimental freeze driers. It provides full product temperature control with shelf temperatures from -60oC to +60oC. Experimental as well as regular temperature systems control the freeze drying with automatic logging of both the freeze drying cycle and product data. Since this is an experimental machine its quite interesting to take a look at all its 'inner' workings.

The full suite of Laboratory freeze driers includes

  • Three research freeze driers

  • & one small scale production machine.

We also have the ability to perform freeze drying of radioactive or radio-labelled samples.  

Basic Introduction to freeze drying.

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Dr Andrew Ingham / Aston University / All copyright with original holders.

Employable Graduates; Exploitable Research