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Dr Peter J. Hanson

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Senior Lecturer in Biochemistry

School of Life and Health Sciences

Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: p.j.hanson@aston.ac.uk
Tel: +44 (0) 121 204 3952
Fax: +44 (0) 121 204 4187

Research Theme

Chronic and Communicable Conditions

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA) 

Teaching Activity on the Biology/BMS Programmes

Teaching of Biochemistry at levels 4-6, Statistics at level 5, and Diseases of the Gastrointestinal Tract at level 6

Teaching Activity on the MPharm Programme

Teaching on second year pharmacology modules 

Career History

Research Interests

  • Applications of preparations of gastric and colonic epithelial cells grown on porous polycarbonate support membranes (Transwells) in biopharmaceutical screening
  • Effects of endotoxin (lipopolysaccharide)  on apoptosis and barrier function in gastric and colonic epithelial monolayers
  • The pharmacology and biochemistry of signal transduction mechanisms in the gastrointestinal tract

Membership of Professional Bodies

  • Biochemical Society

Recent Publications

Absorption and metabolism of chlorogenic acids in cultured gastric epithelial monolayers. Farrell, T. L. , Dew, T. P. , Poquet, L. , Hanson, P. & Williamson, G. Dec-2011 In : Drug metabolism and disposition. 39, 12, p. 2338-2346.
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Physicochemical characterisation, drug polymer dissolution and in vitro evaluation of phenacetin and phenylbutazone solid dispersions with polyethylene glycol 8000. Khan, S. , Batchelor, H. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Oct-2011 In : Journal of pharmaceutical sciences. 100, 10, p. 4281-4294.

Systems biology approach to study permeability of paracetamol and its solid dispersion.  Khan, S. , Elshaer, A. , Rahman, A. S. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Sep-2011 In : International journal of pharmaceutics. 417, 1-2, p. 272-279. 

Genomic evaluation during permeability of indomethacin and its solid dispersion.  Khan, S. , ElShaer, A. , Rahman, A. S. , Hanson, P. , Perrie, Y. & Mohammed, A-U-R. Sep-2011 In : Journal of drug targeting. 19, 8, p. 615-623. 

Use of amino acids as counterions improves the solubility of the BCS II model drug, indomethacin.  ElShaer, A. , Khan, S. , Perumal, D. , Hanson, P. & Mohammed, A-U-R. Jul-2011 In : Current drug delivery. 8, 4, p. 363-372. 

Paracellular permeability is increased by basal lipopolysaccharide in a primary culture of colonic epithelial cells; an effect prevented by an activator of Toll-like receptor-2.  Hanson, P. J. , Moran, A. P. & Butler, K. Jun-2011 In : Innate immunity. 17, 3, p. 269-282. .

High permeability of the anionic form restricts accumulation of indomethacin by cultured gastric surface epithelial cells exposed to low apical pH. Kavvada, K. M., Murray, J. G., Moore, V. A., Coombes, A. G. A. & Hanson. P. J. (2006) Eur. J. Pharmacol. 549, 41-49.

Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen. Durkin, E., Moran, A.P., & Hanson. P.J. (2006).  Journal of Endotoxin Research. 12, 47-56.

Employable Graduates; Exploitable Research