Cell & Tissue Biomedical Research
Aston Research Centre for Healthy Ageing (ARCHA)
For over thirty years, Professor Griffin's major research area has been geared towards understanding the biochemistry, molecular biology and physiology of a group of enzymes referred to as transglutaminases. This group of enzymes is commonly referred to as “protein biological glues” since it can crosslink proteins into stable, high molecular weight structures such as those found in skin, in fibrin cross linking during blood coagulation and in hair.
Focus has been mostly on the tissue transglutaminase (TG2), and in particular, the importance of this enzyme in cell death, matrix deposition and cell adhesion and the relationship of these functions to wound healing, tissue fibrosis and scarring, tumour progression and cystic fibrosis.
Recent work has also been concerned with the use of transglutaminases in the bioengineering of natural polymers for the development of novel biomaterials used in soft (eg: diabetic ulcers and pressure sores) and hard (eg: bone) tissue repair.
Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors. E Badarau, et al, M Griffin. Eur J Med Chem. 66: 526-30.
TG2, a novel extracellular protein with multiple functions. (2013) Wang Z, Griffin M. Amino Acids 42: 939-949.
Recent advances in the development of tissue transglutaminase (TG2) inhibitors (2013). E Badarau, RJ Collighan, M Griffin. Amino Acids 44: 119-127.
C.M. Bergamini, R. Collighan, Z. Wang, M. Griffin. Adv. Enzymology 78:1-46
Transglutaminase 2 cross-linking of matrix proteins - biological significance and medical applications (2009). Collighan R, Griffin M. Amino Acids, 36(4), 659-670.
Tissue transglutaminase in tumour progression : friend or foe? (2007) .P Kotsakis , M Griffin. Amino Acids 33 (2) 373-384.
Tissue tranglutaminase and the stress response (2007). R Ientile, D Caccamo, M Griffin Amino Acids 33 (2) 385-394
Collagen: Structure and Modification for Biomedical Applications (2007). DYS Chau, RJ Collighan and M Griffin. In ‘Trends in Biomaterials Research’. Ed. J Patrick, Nova Publishers.
Tissue transglutaminase (TG2) – a wound response enzyme (2006).D Telci, M Griffin. Frontiers in Bioscience 11 867-882.
Transglutaminase and vascular biology: Physiopathologic implications and perspectives for therapeutic interventions (2005).CM Bergamini, M Griffin, FS Pansini. Current Medicinal Chemistry 12(20):2357-2372.
Transglutaminases in wound healing and inflammation (2005). M Griffin T Johnson and E Verderio.Invited chapter for monograph on “Transglutaminase family of enzymes in series Progress in Experimental and Tumor Research. Karger Group of Publishers, vol 38, pp89-114.