.

Professor Martin Griffin

Professor in Biochemistry

School of Life & Health Sciences 
Aston University
Aston Triangle
Birmingham B4 7ET
UK

Email: m.griffin@aston.ac.uk

Research Group

Cell & Tissue Biomedical Research 

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA)  

Martin Griffin

For over thirty years, Professor Griffin's major research area has been geared towards understanding the biochemistry, molecular biology and physiology of a group of enzymes referred to as transglutaminases.  This group of enzymes is commonly referred to as “protein biological glues” since it can crosslink proteins into stable, high molecular weight structures such as those found in skin, in fibrin cross linking during blood coagulation and in hair. 

Focus has been mostly on the tissue transglutaminase (TG2), and in particular, the importance of this enzyme in cell death, matrix deposition and cell adhesion and the relationship of these functions to wound healing, tissue fibrosis and scarring, tumour progression and cystic fibrosis.

Recent work has also been concerned with the use of transglutaminases in the bioengineering of natural polymers for the development of novel biomaterials used in soft (eg: diabetic ulcers and pressure sores) and hard (eg: bone) tissue repair.

  • President of the European Association for Higher Education in Biotechnology.
  • Fellow of the Institute of Biology.
  • Evaluator for the National Research Foundation of South Africa.
  • EPSRC Peer Review College Member.
  • Previous Panel Member of RAE 2008. 
  • European Doctorate in Biotechnology:added value for European Academia and Industry(2004)
    CFA Bryce, J Aghion, P Bos, F Celada, M Griffin, R Hull,. 
    Biochemistry and Molecular Biology Education 
    32 352-357

TG2, a novel extracellular protein with multiple functions. (2013) Wang Z, Griffin M
Amino Acids 42: 939-949.

Recent advances in the development of tissue transglutaminase (TG2) inhibitors (2013). 
E Badarau, RJ Collighan, M Griffin.  
Amino Acids 44: 119-127.

Structure and Regulation of Type 2 transglutaminase in relation to its physiological functions and pathological roles (2010).

C.M. Bergamini, R. Collighan, Z. Wang, M. Griffin.
Adv. Enzymology 78:1-46

Transglutaminase 2 cross-linking of matrix proteins - biological significance and medical applications (2009). 
Collighan R, Griffin M
Amino Acids36(4), 659-670.

Tissue transglutaminase in tumour progression : friend or foe? (2007) .
P Kotsakis , M Griffin.
Amino Acids 33 (2) 373-384.

Tissue tranglutaminase and the stress response (2007). 
R Ientile, D Caccamo, M Griffin
Amino Acids 33 (2) 385-394

Collagen: Structure and Modification for Biomedical Applications (2007).  DYS Chau, 
RJ Collighan and M Griffin.  In ‘Trends in Biomaterials Research’. Ed.  J Patrick, Nova Publishers.

Tissue transglutaminase (TG2) – a wound response enzyme (2006).
D Telci, M Griffin.
Frontiers in Bioscience 11 867-882.

Transglutaminase and vascular biology: Physiopathologic implications and perspectives for therapeutic interventions (2005).
CM Bergamini, M Griffin, FS Pansini.
Current Medicinal Chemistry 12(20):2357-2372.

Transglutaminases in wound healing and inflammation (2005).
M Griffin T Johnson and E Verderio.
Invited chapter for monograph on “Transglutaminase family of enzymes in series Progress in Experimental and Tumor Research. Karger Group of Publishers, vol 38, pp89-114.

Publications