Professor Helen R. Griffiths

Helen Griffiths

Professor in Biomedical Sciences


Pro-Vice-Chancellor for International Relations

School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET

Email: h.r.griffiths@aston.ac.uk
Tel: +44 (0)121 204 3950
Fax:+44 (0)121 204 5142

Room MB560

Research Group

Cell and Molecular Biomedical Research Group

Research Centre

Aston Research Centre for Healthy Ageing (ARCHA) 

Teaching activity

Member of the Biology Teaching Programme

Career History


  Glenn Award for Ageing Research. 2014.                                                                                                                             Fellow of the Society of Biology. 2011.                                                                                                                               Aston Excellence Award for Outstanding Researcher of the Year 2009.                                                                                    1st Catherine Pasquier Prize. From European Society for Free Radical Research 2004.

Committee Memberships 

Chair, British Society for Research on Ageing 2013-

Chair, UK Deans of Science 2013-

European Society for Free Radical Research.

Biochemical Society Theme Panel III

BBRSC panel D member

Research Interests

  • Nutrient-gene interaction - effects on cellular and plasma proteome
  • Interplay between lipids/sphingolipids and reactive oxygen species
  • Immune cell dysfunction during inflammation and ageing
  • Monocyte-endothelial cell dysfunction during inflammation
  • Intracellular redox regulation of cell survival and adaptation
  • Reversible protein oxidation during signalling, and the effects of irreversible modification on function 

Research Funding

Financial support from Alzheimer’s Research UK (ARUK), BBSRC, COST BM1203, ERDF, Marie Curie ITN, and Industry is gratefully acknowledged.

Boost your career! Get funded for a world class research/training/transfer of knowledge experience at Aston University, Birmingham. Apply for a Marie Skłodowska-Curie Individual Fellowships. Details below.

Eligible Researchers

  • Researchers shall be in possession of a doctoral degree or have at least four years of full-time equivalent research experience.
  • At the time of the deadline for submission, they shall not have resided or carried out their main activity (work, studies, etc) in the country of their host organisation for more than 12 months in the 3 years immediately prior to 11th September 2014.

Preferred Researcher Profile

·         Experience suggests that successful researcher have strong CV’s, with 10+ strong publications (high-ranking, international journals) and a good range of experience (teaching, industry/non-academic, PhD supervision).

The Marie Skłodowska-Curie Individual Fellowships enable eligible applicants to come to Aston University for a period from 12 to 24 months; the aims are to undertake world class research, undertake career development, and transfer knowledge. If you have the time, read the Guide for Applicants, it will enable you to fully appreciate the aims and objectives of the scheme - http://ec.europa.eu/research/participants/portal/doc/call/h2020/h2020-msca-if-2014/1600147-guide_for_applicants_if_2014_en.pdf

If this opportunity sounds interesting follow the 3 steps below.

  1. Identify a potential project theme, take a look at Astons research expertise -http://www.aston.ac.uk/research/groups/
  2. Identify a potential Aston host,you will need to make this selection based on your expertise, and your intended project – be ambitious…think multi-disciplinary, think inter-sectoral…use this opportunity to significantly boost your career

Once you have done this and are satisfied that you have a potentially novel, complimentary theme for a research project;

3.       Send a description of your potential theme, Aston host and a description of the potential project (please keep the description to no more than 250 words), accompanied by your full academic CV to p.r.knobbs@aston.ac.uk

The next call is likely to be published on 12th March 2015  with submission due by 10th September 2015 . If you are interested you must send the requested documents by the end of June/early July for this call. 

ERDF  http://www1.aston.ac.uk/about/news/releases/2012/february/biomarkers-make-their-mark-in-the-west-midlands/



Society Memberships 

European Society for Free Radical Research

Biochemical Society

Nutrition Society

British Society for Research on Ageing

Full Publication Listing

For a list of full publications with abstracts please go to the database PubMed and enter the search term – Griffiths HR.

Recent Publications (2008-2014)

Augustyniak E, Adam A, Wojdyla K, Rogowska-Wrzesinska A, Willetts R, Korkmaz A, Atalay M, Weber D, Grune T, Borsa C, Gradinaru D, Chand Bollineni R, Fedorova M, Griffiths HR. Validation of Protein Carbonyl Measurement; a multi-centre study. Redox biology. 2014.;4C:158-168. doi: 10.1016/j.redox.2014.12.009 

Griffiths HR, Lip GYH. Biomarkers and risk stratification in atrial fibrillation. Circulation. 2014; 130(21): p. 3.

Ruskovska T, Bennett SJ, Brown CR, Dimitrov S, Kamcev N, Griffiths HR. Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation. Free radical research. 2014; Dec 23:1-11. [Epub ahead of print]

Rogowska-Wrzesinska A, Wojdyla K, Nedi O, Baron CP, Griffiths HR. Analysis of protein carbonylation - pitfalls and promise in commonly used methods. Free radical research. 2014;  48(10):1145-62. doi: 10.3109/10715762.2014.944868.

Griffiths HR, Bennett SJ, Olofsson P, Dunston CR. Thioredoxin as a putative biomarker and candidate target in age-related immune decline. Biochemical Society transactions. 2014; 42(4): p. 922-927.

Dias IHK, Polidori MC, Griffiths HR. Hypercholesterolaemia-induced oxidative stress at the blood-brain barrier. Biochemical Society transactions. 2014; 42(4): p. 1001-1005.

Turner JE, Bennett SJ, Bosch JA, Griffiths HR, Aldred S. Ultra-endurance exercise. unanswered questions in redox biology and immunology. 2014; 42(4): p. 989-895.

Rana KS, Griffiths HR, Brown JE, Navas P, Brown J, The interaction between metabolic disease and ageing. Global journal of obesity, diabetes and metabolic syndrome. 2014; 1(1).

Pararasa C, Bailey CJ, Griffiths HR. Ageing, adipose tissue, fatty acids and inflammation. Biogerontology. 2014; Nov 4. [Epub ahead of print]

Griffiths HR, Dias I, Willetts RS, Devitt A. Redox regulation of protein damage in plasma. Redox biology. 2014; 2: p. 430-435.

Dias IHK, Mistry J, Fell S, Reis A, Spickett CM, Polidori MC, Lip GYH, Griffiths HR. Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. Free radical biology and medicine. 2014; 75: p. 48-59.

Choudhury K, Clark J, Griffiths HR. An almond-enriched diet increases plasma α-tocopherol and improves vascular function but does not affect oxidative stress markers or lipid levels. Free radical research. 2014; 48(5): p. 599-606.

Torrão RC, Bennett SJ, Brown JE, Griffiths HR. Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function? Free radical biology and medicine. 2014; 71: p. 26-35.

Dias IHK, Griffiths HR. Oxidative stress in diabetes - circulating advanced glycation end products, lipid oxidation and vascular disease. Annals of clinical biochemistry. 2014; 51: p. 3.

Dias IHK, Polidori MC, Li L, Weber D, Stahl W, Nelles G, Grune T, Griffiths HRPlasma Levels of HDL and Carotenoids are Lower in Dementia Patients with Vascular Comorbidities. Journal of Alzheimer's disease. 2014; 40(2): p. 10.

Russell WR, Baka A, Björck I, Delzenne N, Gao D, Griffiths HR, Hadjilucas E, Juvonen K, Lahtinen S, Lansink M, van Loon L, Mykkänen H, Riccardi G, Östman E, Vinoy S, Weickert MO, Russell WR, Baka A, Björck I, Delzenne N, Gao D, Griffiths HR, Hadjilucas E, Juvonen K, Lahtinen S, Lansink M, van Loon L, Mykkänen H, Riccardi G, Östman E, Vinoy S, Weickert MO. Impact of diet composition on blood glucose regulation. Critical reviews in food science and nutrition. 2013.  Nov 12. [Epub ahead of print] DOI:10.1080/10408398.2013.792772

Ghattas A, Griffiths HR, Devitt A, Lip GY, Shantsila E. (2013)
Monocytes in coronary artery disease and atherosclerosis: where are we now?
J Am Coll Cardiol. 2013 Oct 22;62(17):1541-51. doi: 10.1016/j.jacc.2013.07.043

Dias IH, Chapple IL, Milward M, Grant MM, Hill E, Brown J, Griffiths HR. (2013)
Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro.
PLoS One. 2013 Jun 24;8(6):e66407.

Chapple IL, Matthews JB, Wright HJ, Scott AE, Griffiths HR, Grant MM.(2013)
Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists.
Innate Immun.2013;19(2):152-9.

Weber D, Milkovic L, Bennett SJ, Griffiths HR, Zarkovic N, Grune T.(2013)
Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies.
Redox Biol. 2013 Feb 8;1(1):226-33. 

Ratnayake S, Dias IH, Lattman E, Griffiths HR. (2013)
Stabilising cysteinyl thioloxidation and nitrosation for proteomic analysis.
J Proteomics. 2013 Jun 21. 

Carilho Torrao RB, Dias IH, Bennett SJ, Dunston CR, Griffiths HR.(2013)
Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion.
Chem Cent J. 2013 Sep 5;7(1):150. 

Turner JE, Bennett SJ, Campbell JP, Bosch JA, Aldred S, Griffiths HR. (2013)
The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise.
Free Radic Res. 2013 Oct;47(10):821-8. doi:10.3109/10715762.2013.828836.

Kolamunne RT, Dias IHK, Vernallis AB, Grant MM, Griffiths HR, (2013)
Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species
Redox Biology, Volume 1, Issue 1, 2013, Pages 418-426, ISSN 2213-2317, http://dx.doi.org/10.1016/j.redox.2013.08.002.

Dunston CR, Choudhury K, Griffiths HR. (2012)
Terminal galactose residues on transferrin are increased in mid-life adults compared to young adults.
Proteomics. 2012 Aug 29. doi: 10.1002/pmic.201100506. [Epub ahead of print] PubMed PMID: 22930475

Lam M, Carmichael AR, Griffiths HR. (2012)
An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.
PLoS One. 2012;7(6):e40152. Epub 2012 Jun 27. PubMed PMID: 22761954; PubMed Central PMCID: PMC3384610.

Torr EE, Gardner DH, Thomas L, Goodall DM, Bielemeier A, Willetts R, Griffiths HR, Marshall LJ, Devitt A. (2012)
Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.
Cell Death Differ. 2012 Apr;19(4):671-9. doi: 10.1038/cdd.2011.167. Epub 2011 Nov 25. PubMed PMID: 22117198; PubMed Central PMCID: PMC3307987.

Chapple IL, Matthews JB, Wright HJ, Scott AE, Griffiths HR, Grant MM. (2012)
Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists.
Innate Immun. 2012 Aug 21. [Epub ahead of print] PubMed PMID: 22914919.

Gao D, Pararasa C, Dunston CR, Bailey CJ, Griffiths HR (2012)
Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis
Free Radical Biology and Medicine 2012 (53) 796-806
DOI information: 10.1016/j.freeradbiomed.2012.05.026. Epub Aug 2012

Helen R. Griffiths*1, Christopher R. Dunston*, Stuart J. Bennett*, Melissa M. Grant†, Darren C. Phillips‡ and George D. Kitas. (2011)
Free radicals and redox signalling in T-cells during chronic inflammation and ageing.
Biochemical Society Proceedings 2011 In press.

 Allen EM, Matthews JB, O' Halloran DJ, Griffiths HR, Chapple IL. (2011)
Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.
J Clin Periodontol. 2011 Oct;38(10):894-901. doi: 10.1111/j.1600-051X.2011.01764.x. Epub Aug 24.

Akbar S, Bellary S and Griffiths HR. (2011)
Dietary antioxidant interventions in type 2 diabetes patients: a meta-analysis.
British Journal of Diabetes & Vascular Disease March/April 2011 11(2) 62-6.

Wu Z, Choudhury K, Griffiths HR, Xu J, Ma X. (2011)
A novel silicon membrane-based biosensing platform using distributive sensing strategy and artificial neural networks for feature analysis.
Biomed Microdevices. 2011 Sep 14. [Epub ahead of print].

Dunston CR, Griffiths HR, Lambert PA, Staddon S, Vernallis AB. (2011)
Proteomic analysis of the anti-inflammatory action of minocycline.
Proteomics Clin Appl. 2011 Aug;5(7-8):466. 

Gonenc A, Hacişevki A, Griffiths HR, Torun M, Bakkaloglu B, Simsek B. (2011)
Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass.
Biochemistry (Mosc). 2011 Jun;76(6):677-85.  

Qin L, Bartlett H, Griffiths HR, Eperjesi F, Armstrong RA, Gherghel D. (2011)
Macular pigment optical density is related to blood glutathione levels in healthy individuals.
Invest Ophthalmol Vis Sci. 2011 May 5. [Epub ahead of print] PubMed  PMID: 21546529. 

McNeil SE, Griffiths HR, Perrie Y. (2011)
Polycaprolactone fibres as a potential delivery system for collagen to support bone regeneration.
Curr Drug Deliv. 2011  Jul 1;8(4):448-55. 

Dunston CR, Griffiths HR, Lambert PA, Staddon S, Vernallis AB. (2011)
Proteomic analysis of the anti-inflammatory action of minocycline.
Proteomics. 2011 Jan;11(1):42-51.

 Kolamunne RT, Clare M, Griffiths HR. (2011)
Mitochondrial superoxide anion radicals mediate induction of apoptosis in cardiac myoblasts exposed to chronic hypoxia.
Arch Biochem Biophys. 2011 Jan 15;505(2):256-65.  

Dias IH, Matthews JB, Chapple IL, Wright HJ, Dunston CR, Griffiths HR. (2011)
Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines.
J Clin Periodontol. 2011 Jan;38(1):1-7.

Polidori MC, Pientka L, Nelles G, Griffiths HR.(2010)
Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balance.
Int J Clin Exp Med. 2010 Apr 20;3(2):103-9.

Grant MM, Creese AJ, Barr G, Ling MR, Scott AE, Matthews JB, Griffiths HR, Cooper HJ, Chapple IL. (2010)
Proteomic Analysis of a Noninvasive Human Model of Acute Inflammation and Its Resolution: The Twenty-one Day Gingivitis Model.
J Proteome Res. 2010 Sep 3;9(9):4732-4744.PMID: 20662485 [PubMed - as supplied by publisher]Related citations

Dunston CR, Griffiths HR. (2010)
The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens.
Clin Exp Immunol. 2010 Jul 14. [Epub ahead of print]PMID: 20646005 [PubMed - as supplied by publisher]

Toms TE, Panoulas VF, Douglas KM, Nightingale P, Smith JP, Griffiths HR, Sattar N, Symmons DP, Kitas GD. (2010)
Are Lipid Ratios Less Susceptible to Change With Systemic Inflammation Than Individual Lipid Components in Patients With Rheumatoid Arthritis?
Angiology. 2010 Aug 3.

Pamukcu B, Lip GY, Devitt A, Griffiths HR, Shantsila E.(2010)
The role of monocytes in atherosclerotic coronary artery disease.
Ann Med. 2010 Sep;42(6):394-403

Grant MM, Kolamunne R, Matthews JD, Chapple ILC and Griffiths HR (2010)
Oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria.
J. Clin. Periodontol. 2010 Dec;37(12):1039-48.

Dias HKI, Matthews JB, Wright H, Chapple ILC and Griffiths (2010)
Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines
J. Clin. Periodontol. (in the press).

Li L, Willets RS, Polidori MC, Stahl W, Nelles G, Sies H, Griffiths HR.(2010)
Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance.
Free Radic Res. 2010 Mar;44(3):241-8.PMID: 20166891 [PubMed - in process]Related articles

Phillips DC, Dias HK, Kitas GD, Griffiths HR.(2010)
Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention.
Antioxid Redox Signal. 2010 Mar 15;12(6):743-85.PMID: 19686039 [PubMed - in process]Related articles

Gao D, Griffiths HR, Bailey CJ.(2009)
Oleate protects against palmitate-induced insulin resistance in L6 myotubes.
Br J Nutr. 2009 Dec;102(11):1557-63. Epub 2009 Jul 22.PMID: 19622194 [PubMed - indexed for MEDLINE]Related articles

Toms TE, Panoulas VF, Douglas KM, Griffiths H, Sattar N, Smith JP, Symmons DP, Nightingale P, Metsios GS, Kitas GD. (2009)
Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: evidence for substantial under treatment of lipid associated cardiovascular risk?
Ann Rheum Dis. 2009 Oct 23. [Epub ahead of print]PMID: 19854705 [PubMed - as supplied by publisher]Related articles

Gao D, Bailey CJ, Griffiths HR.(2009)
Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes.
Biochem Biophys Res Commun. 2009 Oct 16;388(2):278-82. Epub 2009 Aug 5.PMID: 19664593 [PubMed - indexed for MEDLINE]Related articles

Griffiths HR, Willetts RS, Grant MM, Mistry N, Lunec J, Bevan RJ.(2009)
In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals.
Br J Nutr. 2009 May;101(10):1432-9. Epub 2008 Oct 24.PMID: 18947437 [PubMed - indexed for MEDLINE]Related articles

Griffiths HR, Willetts RS, Grant MM, Mistry N, Bevan RJ and Lunec J (2009).
In vivo vitamin C supplementation increases PITP expression in peripheral blood leukocytes.
British Journal of Nutrition 101(10), 1432-1439

Toms TE,Panoulas VF, Douglas KMJ, Griffiths HR and Kitas GD. (2008)
Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study.
Arthritis Res Ther.;10(6):R145. Epub 2008 Dec 17.

Griffiths,HR (2008)
Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?
Autoimmun Rev. 2008 Jul;7(7):544-9. Epub 2008 May 5. Review.

Dias, I.H., Marshall, L., Lambert, P.A., Chapple, I.L., Matthews, J.B. and Griffiths, H.R. (2008) Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant.
Infect Immun. 76(1):317-23.

Coleman, M.D., Zilz, T.R., Griffiths, H.R. and Woehrling EK. (2008)
A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.
Basic Clin Pharmacol Toxicol. 102(1):25-9.

 Prof Helen Griffiths / Aston University / last updated October 2013

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