Dr Doina Gherghel MD, PhD, FHEA, Dipl. OB (ABS)

Lecturer in Ophthalmology
School of Life and Health Sciences
Aston University
Birmingham B4 7ET, UK

Email: d.gherghel@aston.ac.uk
Telephone: +44 (0) 121 204 4120

Fax: +44 (0) 121 204 4220

Lecturer on the Undergraduate Optometry Programme

Co-ordinator of the Vascular Research Laboratory 

Research Group

Ophthalmic Research Group (ORG)

Research Centre
Aston Research Centre for Healthy Ageing (ARCHA)  

Centre for Research in Vision and Hearing(CRVH)

  • Sept 2012-to date,  BMEC Honorary Assistant Specialist (glaucoma)
  • Sept 2009-to date Heart of England NHS Trust- Honorary Assistant Specialist (glaucoma)
  • 2006: PhD, School of Life and Health Sciences, Aston University
  • 2004-to date: Aston University: Lecturer in Ophthalmology
  • 2004-2005: Medici Fellow (Technology Transfer Fellowship)
  • 2004-to date: Research Consultant, Aston Academy of Life Sciences
  • 2001-2004: Honorary Trust Fellow, Heartlands and Solihull NHS Trust, Birmingham, UK
  • 2001-2004: Research Fellow, School of Life and Health Sciences, Aston University
  • 1998-2000: Glaucoma Research Fellow, University Eye Clinic, Basel, Switzerland
  • 1999: Doctor, Ophthalmology, University Eye Clinic Iasi, Romania
  • 1995-1998: Registrar in Ophthalmology, University Eye Clinic Iasi, Romania
  • 1988-1994: University of Medicine and Pharmacy, Iasi, Romania
  • General Medical Council, Specialist Register in Ophthalmology
  • Alzheimer’s Research Trust, Midlands Network
  • West Midlands Local Eye Health Network (LEHN)
  • European Vision Clinical Research Network (EVICR)
  • Glaucoma Society (UK and EIRE)
  • European Glaucoma Society (EGS)
  • World Glaucoma Association: Consensus on Ocular Blood Flow
  • FHEA, Fellowship of the Higher Education Academy

Current and Prospective General Research Areas- for more informations click here

  • Personalised medicine 
  • Individual risk factors for cardiovascular disease
  • Ageing and vascular health
  • Systemic and ocular circulation in health ad disease
  • Obesity, sleep and  endothelial function 
  • Glaucoma and vascular disease
  • Alzheimer disease: ocular circulation and endothelial function
  • Alzheimer's disease: vision correction and cognitive function
  • Circadian rhythms in human circulation
  • Oxidative stress in ocular diseases  
  • Intra-ocular drug delivery systems
  • Psychological aspects of vision care
  • Retinal vascular imaging

Research Supervision (Specific Projects) – Current and Past

  • PhD: Ms Emily Scarpello: October 2016-to date.: Ocular markers for healthy ageing
  • Mr Said KarimzadOctober 2013-to date: Ocular health and cardiovascular risk in obese patients undergoing bariatric surgery
  • PhD:  Ms Karma Mohamed Gaber Fathalla; July 2012-to date. Project: Investiating the use of machine learning and data mining techniques in determining the risk of cardiovascular disease
  • PhD: Ms Swathi Seshadri; January 2012-January 2015. Project: Individual vascular signature for cardiovascular risk 
  • PhD: Ms Stephanie Mroczkowska: Janury 2009- January 2012. Project: Ocular and systemic vascular dysfunction in glaucoma and Alzheimer's disease 
  • PhD: Ms Lu Qin: April 2008-November 2011. Project: The effect of ageing on vascular health
  • PhD: Mr Sunni Patel: October 2007-May 2011. Project: Ethnic differences in endothelial function in subjects at risk of type 2 diabetes mellitus
  • PhD: Ms Rebekka Heitmar , October 2005- November 2008. Project: Retinal and systemic vascular reactivity in health and disease
  • Ophthalmic Doctorate project: Mrs Catherine Collin, October 2009-to date:   Evaluation of the optic disc parameters in a normal population in the daily optometric practice : Effect of age, refractive error, , intraocular pressure, blood pressure, and ethnicity.
  • Post Doctoral Research  Fellow: Dr Andras Joo (Marie Curie Fellow). September 2016-to
  • Post Doctoral Research Fellow: Dr Alexandra Benevente-Perez: October 2007-December 2008. Project: Glaucoma and Alzheimer’s disease: vascular associations with multiple neurodegenerative consequences (funded by Alzheimer’s Research Trust-ART)
  • Post Doctoral Reserch Fellow: Dr Helen Smith (2005-2006). Project: New drug delivery system for the treatment of POAG 

Inventions/ Innovations:

Patent: D. Gherghel, B. Conway. A novel chronotherapeutic system for the treatment of primary open-angle glaucoma. P715802EP/1196/ US 2009/0155338 A1

Selected Refereed Journal Articles

  • Patel S. Bellary S, Karimzad S, Gherghel D. Overweight status is associated with extensive signs of microvascular dysfunction and cardiovascular risk. Sci Rep. 2016 31; 6: 32282

  • Fathalla KM, Ekart A, Gherghel D. Cardiovascular risk prediction based on retinal vessel analysis using machine learning. 2016 IEEE International Conference on System, Man and Cybernetics SMC 2016, October 9-12, 2016, Budapest, Hungary

  • Seshadri , Ekart A, Gherghel D. Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals. Acta Ophthalmol 2016; 94: e35-42

  • Seshadri , Mroczkowska SA. Qin L. Patel S, Ekart A, Gherghel D.Systemic circulatory influences on retinal microvascular function in middle-age individuals with low to moderate cardiovascular risk. Acta Ophthalmol 2015; 93: e266-74

  •  L Qin, S. A. Mroczkowska, A. Ekart, S. R. Patel. J. M. GibsonD. Gherghel. Patients with early age-related macular degeneration exhibit signs of macro- and microvascular disease and abnormal blood glutahione levels.Graefes Arch Clin Exp Ophthalmol  2014 Jan;252(1):23-30. doi: 10.1007/s00417-013-2418-0. Epub 2013 Jul 11.

  • Mroczkowska S, Benavente-Pérez A, Patel S, Qin L, Bentham P, Gherghel D. Retinal vascular dysfunction relates to cognitive impairement in Alzheimer's disease. Alzheimer Dis Assoc Disord. 2014; 28: 366-367

  • Gherghel D, Mroczkowska S, Qin L. Reduction in blood glutathione levels occurs similarly in patients with primary-open angle or normal tension glaucoma. Invest Ophthalmol Vis Sci. 2013 May 9;54(5):3333-9. doi: 10.1167/iovs.12-11256.

  • Mroczkowska S, Benavente-Perez, Negi A, A Sung V, Qin L, Patel SR, Gherghel D.Primary open-angle glaucoma vs normal-tension glaucoma: the vascular perspective.. JAMA Ophthalmol. 2013 Jan;131(1):36-43. doi: 10.1001/2013.jamaophthalmol.1

  • Patel SR , Bellary S , Qin L , Balanos GM , McIntyre D, Gherghel DAbnormal retinal vascular reactivity in individuals with impaired glucose tolerance: a preliminary study.  Invest Ophthalmol Vis Sci. 2012 Aug 1;53(9):5102-8. doi: 10.1167/iovs.12-9512.

  • Mroczkowska S, Ekart A, Sung V, Negi A, Qin L, Patel SR, Jacob S, Atkins C, Benavente-Perez A, Gherghel DCoexistence of macro- and micro-vascular abnormalities in newly diagnosed normal tension glaucoma patients.. Acta Ophthalmol. 2012 Nov;90(7):e553-9. doi: 10.1111/j.1755-3768.2012.02494.x. Epub 2012 Sep 23.

  • Qin L, Bartlett H, Griffiths HR, Eperjesi F, Armstrong RA, Gherghel D. Macular pigment optical density is related to blood glutathione levels in healthy individuals..Invest Invest Ophthalmol Vis Sci. 2011 Aug 24;52(9):5029-33. doi: 10.1167/iovs.11-7240

  •  Patel S, Bellary S, Qin L, Gill PS, Taheri S, Heitmar R, Gibson J, Gherghel D. Abnormal retinal vascular function and lipid levels in a sample of healthy UK South Asians. British J Ophthalmol, 2011, Nov;95(11):1573-6. Epub 2011 Mar 1.

  • Heitmar R, Lip GY, Cubbidge R, Gherghel D, Blann A. Altered blood vessel responses in the eye and finger in coronary artery disease.Invest Ophthalmol Vis Sci. 2011 Aug 3;52(9):6199-205. doi: 10.1167/iovs.10-6628.

  •  Heitmar R, Blann A, Cubbidge RP, Lip G, Gherghel D. Continuous retinal vessel diameter measurements - the future of retinal vessel assessment? Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5833-9. Epub 2010 Apr 30.

  • D. Gherghel, SL Hosking, IA Cunliffe, R. Heitmar. Transient cardiac ischaemia and abnormal variations in systemic blood pressure in unselected primary open-angle glaucoma patients. Ophtlalmic Physiol Opt. 2010, 30: 175-181

  • Garhofer G, Bek T, Boehm AG, Gherghel D, Grunwald J, Jeppesen P, Kergoat H, Kotliar K, Lanzl I, Lovasik JV, Nagel E, Vilser W, Orgul S, Schmetterer L.. Use of retinal vessel analyser in ocular blood flow research. Acta Ophthalmol.  2010 Nov;88(7):717-22

  • D. Chiselita, C Danielescu, D. Gherghel. Intraocular pressure after cataract surgery using Provasc, Vascoat either separately or in combination.Oftalmologia. 2008;52(3):91-7.

  • R. Heitmar, D. Gherghel, R.A. Armstrong, R. Cubidge, S.L. Hosking:The effect of voluntary fasting and dehydration on flicker-induced retinal vascular dilation in a healthy individual: a case report. Journal of Medical Case Reports 2008, 2:153

  • D. Gherghel, S.L. Hosking, I.A. Cunliffe, Armstrong RA. First-line therapy with latanoprost 0.005% results in improved ocular circulation in newly diagnosed primary open-angle glaucoma patients: a prospective, 6-month, open-label study. Eye. 2008 Mar;22(3):363-9

  • D. Gherghel, S.L. Hosking, I.A. Cunliffe, Armstrong RA. Autonomic dysfunction in unselected and untreated primary-open angle glaucoma patients: a pilot study. Ophtlalmic Physiol Opt. 2007, 27:336-341

  • D. Gherghel, H.R. Griffiths, E.J. Hilton, I.A. Cunliffe, S.L. Hosking. Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma.Invest Ophthalmol Vis Sci. 2005 Mar;46(3):877-83.

  • E.J. Roff Hilton, S.L. Hosking, D. Gherghel, S. Embleton, I.A. Cunliffe. Beneficial effects of small-incision cataract surgery in patients suffering from primary open-angle glaucoma. Eye 2005; 19:670-675

  • D. Gherghel, S.L. Hosking, I.A. Cunliffe. Abnormal systemic and ocular vascular response to temperature provocation in primary open-angle glaucoma patients: a case for autonomic failure? Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3546-54

  • D. Gherghel, S.L. Hosking, S. Orgul. Autonomic nervous system, circadian rhythms, and primary open-angle glaucoma. Surv Ophthalmol. 2004 Sep-Oct;49(5):491-508. Review.

  • D. Gherghel, S.L. Hosking, S. Mantry, S. Banerjee, S.A Naroo, S. Shah. Corneal Pachymetry in Normal and Keratoconic Eyes: Orbscan II versus Ultrasound. J Cataract Refract Surg 2004; 30:1272-1277

  • K. Gugleta, S. Org�l, P.W. Hasler, T. Picornell, D. Gherghel, J. Flammer. Choroidal vascular reaction to hand-grip stress in subjects with vasospasm and its relevance in glaucoma. Invest Ophthalmol Vis Sci. 2003 Apr;44(4):1573-80

  • S. Shah, S. Naroo, S. Hosking, D. Gherghel, S. Mantry, S. Bannerjee, K. Pedweel, H.S. Bains. Nidek OPD-Scan analysis of normal, keratoconic and penetrating keratoplasty eyes. J Refrect Surg 2003; 19 (2 suppl): S255-259

  • D. W. Evans, S. L. Hosking, D. Gherghel, J. D. Bartlett. Contrast Sensitivity Improves Following Brimonidine Therapy in Primary Open-Angle Glaucoma: A Case for Neuroprotection? Br J Ophthalmol 2003; 87:1463- 1465.

  • P.W. Hasler, S. Org�l, K. Gugleta, H. Vogten, X. Zhao, D. Gherghel, J. Flammer. Vascular dysregulation in the choroid of subjects with acral vasospasm.
    Arch Ophthalmol. 2002 Mar;120(3):302-7

  • K. Gugleta, S. Org�l, I. Flamer, D. Gherghel, J. Flammer. Reliability of confocal choroidal laser Doppler flowmetry. IOVS 2002; 43:723-728

  • C. Bogdanici, D. Gherghel, I. Miron: Actualities in retinoblastoma’s treatment. Oftalmologia, 2001; 50: 48-54

  • D. Gherghel, S. Org�l, K. Gugleta, J. Flammer. Retrobulbar blood flow in glaucoma patients with nocturnal over-dipping in systemic blood pressure.
    Am J Ophthalmol. 2001 Nov;132(5):641-7.

  • D. Gherghel, D. Chiselita. Primary open-angle glaucoma – Identification of vascular risk factors. Oftalmologia, 2001;50:17-27

  • M. Gekkieva, S. Org�l, D. Gherghel, K. Gugleta, C. Pr�nte, J. Flammer. The influence of sex difference in measurements with the Langham Ocular Blood Flow system. Jpn J Ophthalmol, 2001; 45: 528-532

  • P. L�beck, S. Org�l, K. Gugleta, D. Gherghel, M. Gekkieva, J. Flammer. The effect of Timolol on anterior optic nerve blood flow in primary open angle glaucoma patients as assessed by the Heidelberg Retina Flowmeter. J Glaucoma, 2001; 10:13-17

  • D. Gherghel, S. Org�l., K. Gugleta, M. Gekkieva, J. Flammer. Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage.Am J Ophthalmol. 2000 Nov;130(5):597-605.

  • D.Gherghel, S.Org�l, K. Gugleta, P.L�beck, M. Gekkieva, J. Flammer. Interocular differences in optic disc topographic parameters in normal subjects. Curr Eye Res 2000, 20: 276-282

  • D. Gherghel, S.Org�l, B.Dubler, K. Gugleta, P.L�beck, J.Flammer. Is vascular regulation in the central retinal artery altered in persons with vasospasm? Arch Ophthalmol. 1999 Oct;117(10):1359-62.

Scientific Abstracts (most recent)

  • S. Seshadri, L Qin, S. Mroczkowska, S. Patel, D. Gherghel. Circulating blood glutathione levels influence retinal microvascular function in healthy individuals. Acta Ophthalmologica 91 (s252), 0-0, 2013

  • D. Gherghel. Autonomic nervous system dysfunction in glaucoma. EVER NICE, October 2012,
  • D. Gherghel. Alzheimer’s disease and ocular vascular function. EVER 3-6 Oct 2011, Heraklion, Crete

  • L Qin, S Patel, H Bartlett, HR Griffiths, JM Gibson, D. Gherghel. The relationship between the macular pigment optic density and systemic antioxidant defense. APAO, 162- September 2010, Beijing, China

  • S. Mroczkowska, A. Benavente-Perez, S. Patel, L. Qin, P. Bentham, D. Gherghel. Is the eye a window to the mind? Retinal vascular reactivity as a marker for endothelial function in Alzheimer’s disease. EVER, 6-9 October 2010, Crete.

  • R. Heitmar, RP. Cubbidge, D. Gherghel, GY. Lip. Fast Fourier Transform of retinal blood vessel structure and methodology for detection of structural change in smokers and individuals with coronary artery disease. Investigative Ophthalmology and Visual Science : Suppl 2010

  • S. Patel, D. Gherghel, L. Qin, G. Balanos, D. McIntyre, J. Gibson. Endothelial function and vascular risk in South-Asians.Investigative Ophthalmology and Visual Science : Suppl 2010

  • Doina Gherghel, Barbara Conway: Glau-chron: a novel chronotherapeutic drug delivery system for the treatment of glaucoma. The 8th International Symposium of Ocular Pharmacology and Therapuutics, 3-6 December 2009, Rome, Italy

  • S Patel, D Gherghel, R Heitmar, A Benavente- Perez, L QinA Benavente-Perez, D McIntyre, Balanos G, Gibson J. Ocular and systemic endothelial function in the offsprings of diabetics: a pilot study. EVER, October 2009, Portoroz, Slovenia

  • D Gherghel, S Patel, L Qin, R Heitmar  and P Bentham. Endothelial dysfunction and oxidative stress in patients suffering from with Alzheimer disease (AD) or glaucoma. World Glaucoma Congress (WGC), July 2009, Boston, USA

  • A Benavente-Perez, D Gherghel, S Patel, L Qin, R Heitmar  and P Bentham. Abnormal retinal vascular reactivity in patients suffering from Alzheimer's disease or glaucoma; a pilot study. Alzheimer's Research Trust Abnnual Congference, 19th-20th March 2009, London, UK

  • R Heitmar, D Gherghel, GY Lip. Retinal and Peripheral Micro-vascular Reactivity in Patients Suffering From Coronary Artery Disease Investigative Ophthalmology and Visual Science 50: Suppl 2009

  • B. Conway, D.Gherghel. Glau-Chron: Chronotherapeutic drug management for glaucoma. Medical  Futures 2008 Awards, 3 September 2008, London, UK

  • R. Heitmar, D. Gherghel, GY Lip. Peripheral vascular reactivity in patients suffering from CAD. Microcirculation Abnormalities in Vascular Disease: Scientific principles and Clinical Significance, 7th Annual Symposium, September 2008, London, UK

  • B. Conway, D. Gherghel. Glau-Chron: Chronotherapeutic drug management for glaucoma. Medical  Futures 2008 Awards, 3 September 2008, London, UK

  • A. Benavente-Perez, D. Gherghel, P. Bentham. Alzheimer’s disease and glaucoma: neurodegenerative disorders with common vascular risk factors? 3rd Annual Meeting of the Midlands ART Network, 10 June 2008, Coventry, UK

  • D. Gherghel , B. Conway. A novel cronotherapeutic insert for the treatment of glaucoma. Medical Research Society (MRS) meeting, 28 February 2007, London, UK

  • R. Heitmar, D. Gherghel, R.A. Armstrong. The effects of voluntary fasting on retinal and peripheral vessel reactivity – a case study.EVER, October 4-7, 2006, Vilamoura, Portugal

  • I. A. Cunliffe, D. Gherghel, S.L. Hosking, E. Patsoura. Ocular blood flow alterations in newly diagnosed and previously untreated primary open-angle glaucoma patients; relationship to autonomic nervous system function. Annual Meeting of Glaucoma Society (UK and EIRE), December, 2005, London, UK

  • Postgraduate: MOptom (Glaucoma module- module leader; Ophthalmic Doctorate course: Glaucoma module -associate module leader; Therapeutics module- module leader)
  • Third year Posterior Eye and General Ophthalmology  (module leader)
  • Third year Anterior Eye
  • Second year Ophtalmic Instrumentations
  • Ophthalmology referral clinics
  • Ophthalmology Grand Rounds
  • Health research effectiveness
  • Clinical research and patients' safety
  • Individual, group and organisational management
  • Technology transfer management
  • Medical education