Molecular Biomedical Research
Aston Research Centre for Healthy Ageing (ARCHA)
Membrane trafficking pathways target various molecules to their specific destinations within the cell as well as in and out of the cell, and thus are essential for fundamental aspects of eukaryotic life including nutrient uptake, growth factor regulation, synaptic signal transduction, infection, etc. Importance of these pathways is illustrated by the growing number of diseases and cancers associated with defects in these pathways.
A number of reports have shown that various signalling molecules physically associate with endomembranes, thus being ideally placed to control membrane traffic or traffic-mediated signalling. The research in our laboratory aims to understand how membrane trafficking and cell signalling are coupled within the cell.Powerful genetics in combination with the relatively simple cellular complexity of the soil nematode Caenorhabditis elegans has been proven to be beneficial in studying membrane transport and cell signalling pathways in vivo. C.elegans Fibroblast Growth Factor Receptor (FGFR) has been found in a genome-wide RNAi screen as a candidate regulator of constitutive secretion. The main goal of the project is to dissect the role of FGFR in controlling membrane transport.
2009 - Royal Society Dorothy Hodgkin Fellow, Aston University
2008-2009 Royal Society Dorothy Hodgkin Fellow, University of Manchester (UK)
2008 - Postdoctoral Research Fellow, University of Manchester (UK)
2003-2007 Postdoctoral Research Fellow, Rutgers- the State University of New Jersey (USA)
2002-2003 Postdoctoral Research Fellow, University of Medicine and Dentistry of New Jersey (USA)