.

Dr Jonathan A. G. Cox

Lecturer in Microbiology

School of Life & Health Sciences
Aston University
Aston Triangle
Birmingham
B4 7ET

Tel: +44 (0) 121 204 5011
Email: j.a.g.cox@aston.ac.uk
Room: MB438c

Dr Jonathan Cox

 I joined Aston University in 2016 as a Lecturer in Microbiology in the School of Life & Health Sciences (LHS). Prior to that, I was a Research Fellow funded by the Tres Cantos Open Lab Foundation (TCOLF), operated by GlaxoSmithKline (GSK), Madrid under their Diseases in the Developing World directive. I was also previously a Research Associate in the Institute of Microbiology and Infection (IMI) at the University of Birmingham immediately after completing my Ph.D. in Molecular Microbiology and Drug Discovery under the supervision of Prof. Gurdyal Besra. Before that, I completed an undergraduate degree in Medical Biochemistry at University of Birmingham, where my interest in the biology and biochemistry of microorganisms began.

B.Sc. (Hons) Medical Biochemistry

Ph.D. Molecular Microbiology and Drug Discovery

  • Lecturer in Microbiology, School of Life and Health Sciences, Aston University
  • Tres Cantos Open Lab Foundation (TCOLF) Research Fellow, GSK, Madrid
  • Post-doctoral Research Associate, University of Birmingham 
I contribute to Microbiology teaching at undergraduate and postgraduate level on a number of degree programs at Aston University. I also supervise project students and provide pastoral support as an academic tutor. I am actively involved with a number of outreach and public engagement activities.
My research interests surround the discovery of new antibiotics and identifying the exact mechanism by which those antibiotics kill bacteria. Finding new “mechanisms of action” reveals new drug targets that can be exploited in the battle against antimicrobial resistance (AMR). AMR accounts for around 700,000 deaths per annum globally and that number is predicted to rise to 10 million by 2050. The current economic burden of AMR is estimated to be at least €1.5 billion per year in the EU. New antibiotics and an improved understanding of how to use them will help to slow the progression of AMR, saving countless lives in the future.
I am available to supervise PhD students with an interest in antibiotics and mechanisms of action.

Member of the Acid Fast Club, UK
Member of the Royal Society of Biology (MRSB)
Member of the Biochemical Society
Member of the Microbiology Society
Member of the British Society for Antimicrobial Chemotherapy (BSAC)
 

Abrahams KA*, Cox JAG*, Spivey VL, Loman NJ, Pallen MJ, et al. (2012) Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB. PLoS ONE 7(12): e52951. doi:10.1371/journal.pone.0052951 *These authors contributed equally to this work

Gurcha S, Veeraraghavan U, Cox JAG, Futterer K, Abrahams K, Bhatt A, Alderwick L, Reynolds R, Loman N, Alemparte C, Barros D, Lloyd A, Ballell L and Besra G (2014). Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS. PLoS ONE 9(11): e113568. doi:10.1371/journal.pone.0113568

Mugumbate G, Abrahams KA, Cox JAG, Papadatos G, van Westen G, et al. (2015) Mycobacterial Dihydrofolate Reductase Inhibitors Identified Using Chemogenomic Methods and In Vitro Validation. PLoS ONE 10(3): e0121492. doi:10.1371/journal.pone.0121492

Jankute M, Cox JAG, Harrison J and Besra G (2015). Assembly of the mycobacterial wall. Annual Review of Microbiology 69:405-423

Cox JAG*, Abrahams K*, Alemparte C, Ghidelli-Disse S, Rullas J, Singh A, Gurcha S, Nataraj V, Remuiñan M, Encinas L, Jervis P, Bhatt A, Kruse U, Bantscheff M, Fütterer K, Barros D, Ballell L, Drewes G and Besra G (2016). Target assignment of THPP inhibitors reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nature Microbiology 1(15006): doi:10.1038/nmicrobiol.2015.6

Abrahams KA, Chung C, Ghidelli-Disse S, Rullas J, Rebollo-Lopez M, Gurcha SS, Cox JAG et al. (2016). A new anti-tubercular scaffold targets KasA with a novel mode of action. Nature Communications 7(12581):doi:10.1038/ncomms12581

Cox JAG, Worthington T (2016). The ‘Antibiotic Apocalypse’ - Scaremongering or Scientific Reporting? Trends in Microbiology
http://dx.doi.org/10.1016/j.tim.2016.11.016

Cox JAG, Mugumbate G, Vela-Glez Del Peral L, Jankute M, Abrahams KA et al. (2016). Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput screen. Scientific Reports doi: 10.1038/srep38986 http://www.nature.com/articles/srep38986
 

Recent Publications