.

Dr Irundika Dias

Research Fellow

School of Life & Health Sciences
Aston University
Aston Triangle
Birmingham
B4 7ET

Tel: 0121 204 5111
Email: h.k.i.dias1@aston.ac.uk
Room number: MB649
Office hours: 8.30am - 4.30pm

Research Group

Cell & Tissue Biomedical Research

Dr Irundika Dias profile photo
  • 2017-todate     Post graduate Diploma in Learning and Teaching in HE
  • 2016     Post graduate certificate of Learning and Teaching in HE
  • 2009     PhD in Biomedical Sciences, Aston University, Birmingham
  • 2004     MSc in Medical Genetics with Immunology, Brunel University, London
  • 2003     BSc in Biochemistry and Molecular Biology, University of Colombo, Sri Lanka
  • 2014-to date     Research Fellow, Aston University
  • 2009-2014     Post-doctoral Researcher, Aston University
  • 2005     Honorary Research Student, National Blood Services, London
  • 2004     Research Assistant, Industrial Technology Institute, Sri Lanka
  • 2003-2004     Teaching Assistant, Department of Chemistry, University of Colombo, Sri Lanka
  • Fellow of Higher Education Academy

  • Biology key skills module (BY1KS1) tutor

  • Research project supervisor for undergraduate final year and masters of Biology research projects.

The primary focus of my current research is investigating the role of oxidative stress and lipid oxidation in chronic diseases. In particular, I am investigating lipid oxidation products in chronic kidney disease and Alzheimer’s disease. Oxidative stress, an imbalance of oxidants and antioxidants in the favour of oxidants, has been thought to play a central part in the complications of many diseases. Lipid oxidation products are formed as a result of increased oxidants or by enzymatic pathways. These products are virtually present in every cellular systems and in circulation and participate in orchestrating many cellular processes as bio active lipid mediators.

During the inflammation, bio active lipids play a pivotal role by recruiting phagocytes first in to the site of infection/injury. Late inflammatory process is actively limited by activation of a resolution phase, often via generation of structurally specific oxidised lipids whose function is to orchestrate resolution of inflammation. Imbalance of these processes result chronic inflammation and disease progression.

We use cell culture model systems and primary blood cell isolations and take various approaches; molecular biology, immunoassay, proteomic and lipidomic tools, to study protein and lipid oxidation in cells and tissue. My previous work heavily involved studying hyperactive behaviour of human neutrophils towards chronic periodontitis. Recent work in the lab on monocyte shows promising approach to study inflammatory cascades and how lipids involve in this process.

We have recently developed new mass spectrometry-based approach (LC-MS/MS) to analyse cholesterol oxidation and phospholipid oxidation products in biological fluids, cell and tissue.

Mr. Ali Remtulla  

Title: The effect of oxidative stress on thioredoxin-1 in T cells and associated binding partners

  • January 2017     ARUK network grant: Do oxysterols induce mitochondrial impairment and neuronal toxicity in Alzheimer’s disease? £4700
  • February 2016     ARUK network grant: Oxysterol homeostasis in AD £3950
  • 2014-2017     Kidney Research UK fellowship award:Periodontitis as a co-morbidity for adverse cardiovascular outcomes in patients with chronic kidney disease; do plasma lipids provide a critical link? £185,619
  • September 2016     Poster prize: ARUK midlands network
  • January 2013     Poster Prize for the best poster at Biochemical Society hot topic meeting titled "Nutrient mechanisms in inflammation, infection and immunity"
  • July 2010     President’s prize for the best periodontology research
  • June 2006     Best poster at Aston University to go towards Regional competition
  • Society for Free Radical Research- Europe (SFRR-E)
  • Higher Education Academy (HEA)
  • Biochemical Society
  • International Association for Dental Research (IADR)

Recent Publications