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Dr Alan Goddard

Lecturer in Biochemistry

School of Life & Health Sciences

Aston University
Birmingham
B4 7ET

Tel: + 44(0)121 204 3178
Email: a.goddard@aston.ac.uk
Room: MB438T

Dr Alan Goddard

I joined the School of Life & Health Sciences in October 2016 as a Lecturer in Biochemistry, having spent the previous four years as a Senior Lecturer in Biochemistry at the University of Lincoln.  Prior to that I spent nearly seven years as a postdoctoral researcher at the University of Oxford.  I completed both my BSc and PhD at the University of Warwick.

BSc (Hons) Biological Sciences with Molecular Genetics, University of Warwick, 2002.

PhD Biological Sciences, University of Warwick, 2006.
PGCE HE, University of Lincoln, 2016.

2016 – date: Lecturer in Biochemistry, School of Life and Health Sciences, Aston University.
2012 – 2016: Senior Lecturer in Biochemistry, School of Life Sciences, University of Lincoln.
2009 – 2012: PDRA, University of Oxford with Prof. Anthony Watts and Dr Mark Wallace.
2006 – 2009: PDRA, University of Oxford with Prof. Stuart Ferguson, Prof. David Richardson (UEA) and Dr James Moir (York).

I teach across the breadth of life sciences at undergraduate and postgraduate but my main focus in within the area of biochemistry.  I also supervise final year project students and provide academic and pastoral care to tutees.  I am very involved in public engagement and outreach – please get in touch if you would like to know more.

I am module leader for BY2BC1 - Metabolism and BY3BC1 - Medical Biochemistry.

I am Programme Director for the BSc Biochemistry.

My research interests focus around membrane proteins and the lipid membranes in which they reside.  I have experience of working with a range of membrane protein systems including receptors such as GPCRs, transporters and biogenesis systems.  I use model lipid membranes to study proteins in their native environments and also to probe the effects of various compounds on the integrity of the membrane itself.  For example, I have investigated the lipid-specific effects of antimicrobials and solvent on biological membranes. I have an ongoing collaboration with Green Biologics Ltd.
I am keen to collaborate on industrially-focussed projects as well as academic ones.  Please get in touch if you would like to know more.

Current:

  • October 2017-February 2018   IB Catalyst Seeding Award - BioProNet (£24,968).  Improved microfluidic devices for downstream bioprocess separation of sub-micron targets with uFraction8 Ltd.
  • October 2017-September 2020    School of Life and Health Sciences PhD Studentship (£54,888). Engineering bacteria for enhanced production of high-value chemicals.
  • October 2017-January 2018  BBSRC UK-Taiwan Exchange (£1,200). Exchange with Dr Yu-Chu Chang, College of Medical Science and Technology, Taipei Medical University.
  • September 2017-December 2017   Biochemical Society Event Sponsorshop (£350) Labtathlon.
  • August 2017-February 2018     IB Catalyst Seeding Award - CBMNet Flagship Project (£100,000). Consolidation, Integration and Critical Mass Building- Optimizing membrane function in the Clostridial ABE process with Dr Gavin Thomas. Dr Rob Fagan, Dr Peter Chivers and Green Biologics Ltd. 

Completed:

  • October 2016    BBSRC CBMNet Industrial-Academic Exchange Grant (£850). Examination of n-butanol membrane interactions by nanoplasmonic sensing.
  • March 2016-November 2016    BBSRC CBMNet Proof of Concept (£30,753.20).Identifying and characterising protective lipid changes under solventogenic stress with Dr Ian Graham and Dr Tony Larson (University of York) and Green Biologics Ltd.
  • June-July 2016    BBSRC CBMNet Vacation Scholarship (£1,467). Modelling of multifactorial solvent stress on membranes.
  • June 2016    BBSRC CBMNet Public Engagement Grant (£460).School debate: how should we use our resources?
  • March 2016-August 2016    BBSRC CBMNet Business Interaction Voucher (£9,820.15 + £10,000 in kind)In vitro and in silico models of n-butanol-membrane interactions with Dr Manuela Mura (School of Maths and Physics) and Green Biologics Ltd.
  • January 2016-December 2016    School of Life Sciences Pump Priming Scheme (£10,000). Characterising peptide-guided drugs.  With Driton Vllasaliu (School of Pharmacy, University of Lincoln).
  • June-August 2015    University of Lincoln UROS Scheme (£1,000).Support for an undergraduate student identifying novel cell-surface receptors.
  • November 2014 - April 2015    BBSRC CBMNet Business Interaction Voucher (£4,895 + £5,000 in kind). n-butanol Interactions with Biological Membranes with Green Biologics Ltd.
  • October 2014 -June 2015    Fund for Educational Development (£1,400).To develop a new training programme for PGR students focussed on employability.
  • June 2014 – August 2015    Eric Reid Fund for Methodology - Biochemical Society (£1,837).To develop a collaboration with Dr Nicola Crewe to use Polarising Light Microscopy to study biological lipid membranes.
  • June 2014-July2014    University of Lincoln UROS Scheme (£1,000).With Dr Anna Wilkinson and Dr Charles Deeming.  Summer studentship support for two students to study the biochemistry of bird eggs.
  • November 2013 - April 2014    University of Lincoln RIF (£12,700).With Dr Driton Vllasaliu and Dr David Waugh.  Pump prime funding to develop an in vitro model of the human gut using laser-processing techniques.
  • July 2013    Biochemical Society Sponsored Event Grant (£350). School of Life Sciences Postgraduate Symposium
  • June – August 2013    SGM Harry Smith Vacation Studentship (£1,766).Purification of Paracoccus nitrogen oxyanion transporters.

 

Current Members:

  • Dr Sarah Routledge - Optimisation of the ABE process in Clostridia.
  • Daniel Wiseman - PhD/GTA.  Interactions of GPCRs and RAMPs.
  • John Linney - PhD - Engineering Clostridia for production of high-value chemicals.
  • Georgia Stevens - Placement student.
  • Charlotte Brady - Placement student.

 Lab Alumni:

  • Dr Peter Sanderson - Postdoctoral Researcher.  Solventogenic stress in bacteria.  Now at University of Lincoln.
  • Samantha Penrice - Postdoctoral Researcher.  Geometric morphometric analysis of GPCR structures.
  • Joanna Bird - MSc student.  Peptide-guided drug delivery.  Now at University of Kent.

I am happy to supervise PhD students in the areas of membrane proteins and lipid membranes.  Please email me if you are interested in joining my laboratory.
  • Member of Biochemical Society (Local Ambassador and Member of Training Theme Panel).
  • Member of Microbiology Society.
  • Member of British Biophysical Society.
  • Senior Fellow of Higher Education Academy.

Publications since 2010:

  1. Goddard, A.D., Bali, S., Mavridou, D.A.I, Luque-Almagro, V.M., Gates, A.J., Roldán, M.D., Newstead, S., Richardson, D.J. and Ferguson, S.J. (2016) The Paracoccus denitrificans nitrate and nitrite transporters; probing nitrate uptake and nitrate/nitrite exchange mechanisms.  Molecular Microbiology In Press
  2. Goddard, A.D., Dijkman, P.M., Adamson, R.J., Inácio dos Reis, R. and Watts, A. (2015) Reconstitution of membrane proteins with a GPCR as an example.  Methods in Enzymology. 556, 405-424.
  3. Goddard, A.D., Dijkman, P.M, Adamson, R.J. and Watts, A. (2013) Lipid-dependent GPCR dimerisation. Methods in Cell Biology 117, 341-357.
  4. Basu, S., Leonard, J.C., Desai, N., Mavridou, D.A., Tang, K.H., Goddard, A.D., Ginger, M.L., Lukes, J. and Allen, J.W. (2013) Divergence of Erv1-associated mitochondrial import and export pathways in trypanosomes and anaerobic protists. Eukaryot. Cell 12, 343-355.
  5. Goddard, A.D. and Watts, A. (2012) Contributions of fluorescence techniques to understanding G protein-coupled receptor dimerisation. Biophys. Rev. 4, 291-298.
  6. Goddard, A.D. and Watts, A. (2012) Regulation of G protein-coupled receptors by palmitoylation and cholesterol. BMC Biology  10:27.
  7. Stevens, J.M., Mavridou, D.A.I, Hamer, R., Kritsiligkou, P., Goddard, A.D. and Ferguson, S.J. (2011) Cytochrome c biogenesis system I. FEBS J. 278, 4170-4178 [One of the top 12 most-cited FEBS Journal papers two years from publication.]
  8. Mavridou, D.A.I, Saridakis, E., Kritsiligkou, P., Goddard, A.D., Stevens, J.M., Ferguson, S.J. and Redfield C. (2011). Oxidation-state-dependent protein-protein interactions in disulphide cascades. J. Biol. Chem. 286, 24943-24956.
  9. Gates, A.J., Luque-Almagro, V.M., Goddard, A.D., Ferguson, S.J., Roldán, M.D. and Richardson, D.J. (2011) A composite biochemical system for bacterial nitrate and nitrite assimilation as exemplified by Paracoccus denitrificans. Biochem. J. 453, 743-753
  10. Selmi, D.N., Adamson, R.J., Attrill, H., Goddard, A.D., Gilbert, R.J.C., Watts, A. and Turberfield, A.J. (2011) DNA-templated protein arrays for single-molecule imaging. Nano Lett. 11, 657-60
  11. Tapaneeyakorn, S., Goddard, A.D., Oates, J., Willis, C.L. and Watts, A. (2010) Solution- and solid-state NMR studies of GPCRs and their ligands.  BBA-Biomembranes 1808, 1462-1475.
  12. Goddard, A.D., Stevens, J.M., Rao, F., Mavridou, D.A., Chan, W.L., Richardson, D.J., Allen, J.W. and Ferguson, S.J. (2010) c-type cytochrome biogenesis can occur via a natural Ccm system lacking CcmH, CcmG and the heme-binding histidine of CcmE. J. Biol. Chem. 285, 22882-22889
For my full publication list please see Google Scholar
 

 

Recent Publications