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Dr Andrew Devitt

Reader in Inflammatory Cell Biology


Fellow of the Higher Education Academy
Fellow of the Royal Society of Biology
Fellow of the Institute of Biomedical Science

Director of Research for the Cell & Tissue Biomedical Research Group


School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET
UK

email: a.devitt1@aston.ac.uk
telephone: +44 (0) 121 204 4165
fax: +44 (0) 121 204 4187
Book an appointment here

We welcome enquiries from PhD-qualified researchers from all countries outside the UK wishing to apply for a European Commission-funded Marie Sklodowska-Curie Individual Fellowship to come to work with us at Aston. Subject areas might include inflammation, extracellular vesicles, cell death and the regulation of innate immune responses.  Please contact Andrew Devitt for further details.


Research Group

Cell & Tissue Biomedical Research 

Research Centre

Member of the Aston Research Centre for Healthy Ageing


Member of the Biology and Pharmacy Teaching Programmes 

UK Centre for Bioscience Representative

Career History

Dr Andrew Devitt
Dr Andrew Devitt
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Research Interests

  • Apoptotic cell-derived extracellular vesicles (ACdEV) – structure/function relationships
  • Molecular mechanisms underlying recognition and clearance of apoptotic cell and pathogens
  • Monocyte and macrophage biology and innate immunity
  • Monocytes and macrophages in ageing and cardiovascular disease
  • Apoptosis & Identification of apoptotic cells
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 Projects and Funding

  • Refining an in vitro system of predictive biomarkers of in vivo liposome efficacy.                                 Nc3Rs £90,000. 2016-2019.
  • Secretome of canine mesenchymal stem cells. BBSRC iCASE £90,000 (2015-19). Co-I with Dr WEB Johnson.
  • How death influences life: Unlocking the apoptotic cell-derived extracellular vesicle (acdEV) and linking composition to immune function. BBSRC responsive mode grant: £555,823) (2015-18). Collaborative grant with co-Is Dr Sam Griffiths-Jones (Manchester); Profs Griffiths & Perrie (Aston) and Prof Charles Serhan (Harvard Medical School, Boston, US).
  • A2D: attracted to death -understanding how extracellular vesicles interact with the immune system. BBSRC iCASE £94,126 (2014-2018).
  • Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy. Nc3Rs £74,625 (2013-2014).
  • Drawn towards death – understanding this morbid fascination. British Society for Cell Biology: Studentship. (2013).
  • Characterisation of transglutaminase-2 activity on human macrophages and its role in chemoattraction to apoptotic bodies released during cell death.  Wellcome Trust Studentship. (2012).
  • Investigation of molecular mechanisms underlying the role of ICAM-3 in the phagocytic clearance of apoptotic leukocytes. BBSRC Research Grant £444, 088 (2007-2010)  

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  • Characterisation of the innate immune system in the clearance of apoptotic cells.  Aston University studentship. (2008-2011).

  • Evaluation of monocyte/macrophage function throughout the ageing process. BBSRC Targeted Priority Studentship. (2009-2012).

  • Analysis of the role of transglutaminase 2 in macrophage function. Aston University Bursary Scheme. (2009-2012).

  • Characterisation of the molecular constitution of apoptotic bodies released during cell death and their role in macrophage chemoattraction. Biochemical Society Studentship. (2009).

  • A versatile stem cell model of Alzheimer’s disease.  Co-applicant with Prof. Coleman and Drs. Eric Hill & Ann Vernallis. (2009).

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   Book Chapters

  • Devitt, A. & Gregory, C. D. (2008).
    Innate immune mechanisms in the resolution of inflammation.
    In: Progress in Inflammation Series. The resolution of Inflammation. pp39-56.  Eds: Rossi, A. & Sawatzky, D.; Birkhäuser Verlag AG. [Online]

  • Devitt, A. & Gregory, C. D. (2004).
    Measurement of apoptotic cell clearance in vitro.
    In: Methods in Molecular Biology282:207-22. [Online]

  • Gregory, C. D. & Devitt, A. (2003).
    Innate Immunity and Apoptosis: CD14 dependent clearance of apoptotic cells.  In: Apoptosis and Autoimmunity.  Pp 111-132.  Eds: Herrmann, M. & Kalden, J. R.  Wiley-VCH. [Online]

  • Devitt, A., Lund, P. A., and Pearce, J. H. (1994)
    Cytokine-independent induction of nitric oxide during the initiation of chlamydial infection.
    Proceedings of the Eight International Symposium on Human Chlamydial Infections, pp. 411-414.  


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Book Reviews

  • Devitt, A. (2009). 
    Inflammation Research. DOI : 10.1007/s00011-009-0151-2. [Online]

  • Devitt, A. (2009). 
    Inflammopharmacology. DOI : 10.1007/s10787-009-0024-x. [Online]

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Recent Publications