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Professor Andrew Devitt

Chair in Inflammatory Cell Biology

Head of Biomedical  & Biological Sciences

Fellow of the Higher Education Academy

Fellow of the Royal Society of Biology

Fellow of the Institute of Biomedical Science

Director of Research for the Cell & Tissue Biomedical Research Group

School of Life and Health Sciences
Aston University

Aston Triangle
Birmingham
B4 7ET
UK

email: a.devitt1@aston.ac.uk
tel:
+44 (0) 121 204 4165
fax:
+44 (0) 121 204 4187
Book an appointment here

We welcome enquiries from PhD-qualified researchers from all countries outside the UK wishing to apply for a European Commission-funded Marie Sklodowska-Curie Individual Fellowship to come to work with us at Aston. Subject areas might include inflammation, extracellular vesicles, cell death and the regulation of innate immune responses.  Please contact Andrew Devitt for further details.


Research Group

Cell & Tissue Biomedical Research 

Research Centre

Member of the Aston Research Centre for Healthy Ageing

Member of the Biology and Pharmacy Teaching Programmes 

UK Centre for Bioscience Representative

Dr Andrew Devitt
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Research Interests

  • Apoptotic cell-derived extracellular vesicles (ACdEV) – structure/function relationships
  • Molecular mechanisms underlying recognition and clearance of apoptotic cell and pathogens
  • Monocyte and macrophage biology and innate immunity
  • Monocytes and macrophages in ageing and cardiovascular disease
  • Apoptosis & Identification of apoptotic cells
  • Extracellular vesicles (EV) – understanding the molecular mechanisms of tissue homeostasis and repair.

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 Projects and Funding

2016 – 2019

Refining an in vitro system of predictive biomarkers of in vivo liposome efficacy.
Nc3Rs £90,000.

2015 – 2019

Secretome of canine mesenchymal stem cells. BBSRC iCASE £90,000. Co-I with Dr WEB Johnson.

2018 Towards defining the functional surface of EV in dementia. Alzheimer’s Research UK £70,000. 

2015 – 2018

How death influences life: Unlocking the apoptotic cell-derived extracellular vesicle (acdEV) and linking composition to immune function. BBSRC responsive mode grant: £555,823). Collaborative grant with co-Is Dr Sam Griffiths-Jones (Manchester); Profs Griffiths & Perrie (Aston) and Prof Charles Serhan (Harvard Medical School, Boston, US).

2014 - 2018

A2D: attracted to death -understanding how extracellular vesicles interact with the immune system. BBSRC iCASE £94,126. 

2013 – 2014

Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy. Nc3Rs £74,625.

2013

Drawn towards death – understanding this morbid fascination. British Society for Cell Biology: Studentship.

2012

Characterisation of transglutaminase-2 activity on human macrophages and its role in chemoattraction to apoptotic bodies released during cell death.  Wellcome Trust Studentship.

2009 - 2012

Evaluation of monocyte/macrophage function throughout the ageing process. BBSRC Targeted Priority Studentship.

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2009 – 2012

Analysis of the role of transglutaminase 2 in a macrophage function. Aston University Bursary Scheme.

2008 – 2011  

Characterisation of the innate immune system in the clearance of apoptotic cells. Aston University Studentship.

2007 - 2010

Investigation of molecular mechanisms underlying the role of ICAM-3 in the phagocytic clearance of apoptotic leukocytes. BBSRC Research Grant £444,088.

2009

Characterisation of the molecular constitution of apoptotic bodies released during cell death and their role in macrophage chemoattraction. Biochemical Society Studentship.

2009

A versatile stem cell model of Alzheimer's disease. Co-applicant with Prof. Coleman, Dr. Eric Hill and Dr Ann Vernallis

Andrew Devitt web page - pic 3
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Recent Publications