Dr Andrew Devitt

Reader in Inflammatory Cell Biology

Fellow of the Higher Education Academy
Fellow of the Royal Society of Biology
Fellow of the Institute of Biomedical Science

Director of Research for the Cell & Tissue Biomedical Research Group

School of Life and Health Sciences
Aston University
Aston Triangle
Birmingham B4 7ET

email: a.devitt1@aston.ac.uk
telephone: +44 (0) 121 204 4165
fax: +44 (0) 121 204 4187
Book an appointment here

We welcome enquiries from PhD-qualified researchers from all countries outside the UK wishing to apply for a European Commission-funded Marie Sklodowska-Curie Individual Fellowship to come to work with us at Aston. Subject areas might include inflammation, extracellular vesicles, cell death and the regulation of innate immune responses.  Please contact Andrew Devitt for further details.

Research Group

Cellular & Tissue Biomedical Research 

Research Centre

Member of the Aston Research Centre for Healthy Ageing

Member of the Biology and Pharmacy Teaching Programmes 

UK Centre for Bioscience Representative

Career History

Dr Andrew Devitt
Dr Andrew Devitt
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Research Interests

  • Apoptotic cell-derived extracellular vesicles (ACdEV) – structure/function relationships
  • Molecular mechanisms underlying recognition and clearance of apoptotic cell and pathogens
  • Monocyte and macrophage biology and innate immunity
  • Monocytes and macrophages in ageing and cardiovascular disease
  • Apoptosis & Identification of apoptotic cells
Andrew Devitt web page - pic 1

 Projects and Funding

  • Secretome of canine mesenchymal stem cells. BBSRC iCASE £90,000 (2015-19). Co-I with Dr WEB Johnson.
  • How death influences life: Unlocking the apoptotic cell-derived extracellular vesicle (acdEV) and linking composition to immune function. BBSRC responsive mode grant: £555,823) (2015-18). Collaborative grant with co-Is Dr Sam Griffiths-Jones (Manchester); Profs Griffiths & Perrie (Aston) and Prof Charles Serhan (Harvard Medical School, Boston, US).
  • A2D: attracted to death -understanding how extracellular vesicles interact with the immune system. BBSRC iCASE £94,126 (2014-2018).
  • Towards an in vitro system of predictive biomarkers of in vivo liposome efficacy. Nc3Rs £74,625 (2013-2014).
  • Drawn towards death – understanding this morbid fascination. British Society for Cell Biology: Studentship. (2013).
  • Characterisation of transglutaminase-2 activity on human macrophages and its role in chemoattraction to apoptotic bodies released during cell death.  Wellcome Trust Studentship. (2012).
  • Investigation of molecular mechanisms underlying the role of ICAM-3 in the phagocytic clearance of apoptotic leukocytes. BBSRC Research Grant £444, 088 (2007-2010)  

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  • Characterisation of the innate immune system in the clearance of apoptotic cells.  Aston University studentship. (2008-2011).

  • Evaluation of monocyte/macrophage function throughout the ageing process. BBSRC Targeted Priority Studentship. (2009-2012).

  • Analysis of the role of transglutaminase 2 in macrophage function. Aston University Bursary Scheme. (2009-2012).

  • Characterisation of the molecular constitution of apoptotic bodies released during cell death and their role in macrophage chemoattraction. Biochemical Society Studentship. (2009).

  • A versatile stem cell model of Alzheimer’s disease.  Co-applicant with Prof. Coleman and Drs. Eric Hill & Ann Vernallis. (2009).

Andrew Devitt web page - pic 3

Recent Publications

  • Devitt, A., Oguejiofor, W. O., Willetts, R. S., Griffiths, H. R. & Marshall, L. J. (2015). Developing Relevant, Accurate Models Of Human Airways. JPP: DOI: 10.1111/jphp.12340. (Online).
  • Nadella, V., Wang, Z., Johnson, T. S., Griffin, M. & Devitt, A. (2015) Transglutaminase 2 interacts with syndecan 4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells. BBA – Molecular Cell Research: 1853(1): 201-12. (Online).
  • Devitt, A., Oguejiofor, W. O., Willetts, R. S., Griffiths, H. R. & Marshall, L. J. (2014). Developing Relevant, Accurate Models Of Human Airways. JPP: Accepted.

  • Nadella, V., Wang, Z., Johnson, T. S.,Griffin, M. & Devitt, A. (2014) Transglutaminase 2 interacts with syndecan 4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells. BBA – Molecular Cell Research: In press
  • Chimonides, G. F., Behrendt, J. M., Chundoo, E., Bland, C., Hine, A. V., Devitt, A., Nagel, D. A. & Sutherland, A. J. (2014) Cellular uptake of ribonuclease A-functionalised core-shell silican microspheres. Journal of Materials Chemistry B: Advance Article.DOI:10.1039/C4TB01130A. (Online)

  • Nagel, D. A., Behrendt, J. M., Torr, E. E., Prince, M., Devitt, A., Sutherland, A. J. & Hine, A. V. (2014) Polymeric Microspheres as Protein Transduction Reagents. Molecular and Cellular Proteomics 13: 1543-1551.[Online].
  • Griffiths, H. R., Dias, I. H. K., Willetts, R. S. & Devitt, A. (2014) Redox regulation of protein damage in plasma. Redox Biology. 2: 430-5. [Online] 
  • Kaur, R., Henrikson-Lacey, M., Wilkhu, J., Devitt, A., Christensen, D. & Perrie, Y. (2014).  Effect of incorporating cholesterol into DDA:TDB liposomal adjuvants on Bilayer properties, biodistribution, and immune responses. Molecular Pharmaceutics. 11(1): 197-207. [Online]
  • Hawkins, L. A. & Devitt, A. (2013) Current Understanding of the mechanisms for clearance of apoptotic cells. Accepted: Journal of Cell Death: 6: 57-68. [Online]
  • Ghattas, A., Griffiths, H. R., Devitt, A., Lips, G. Y. H. & Shantsila, E. (2013) Monocyte in coronary artery disease and atherosclerosis: where are we now?  Journal of the American College of Cardiology: doi:10.1016/j.jacc.2013.07.043 [Online]
  • Thomas, L., Bielemeier, A., Lambert, P. A., Darveau, R. P., Marshall, L. J. and Devitt, A. (2013) The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells. PLoS ONE: 8(7): e70691. doi:10.1371/journal.pone.0070691 [Online]

  • Hill EJ, Nagel DA, O’Neil JD, Torr E, Woehrling EK, et al. (2013) Effects of Lithium and Valproic Acid on Gene Expression and Phenotypic Markers in an NT2 Neurosphere Model of Neural Development. PLoS ONE 8(3): e58822. doi:10.1371/journal.pone.0058822 [Online]

  • Tennant, I., Pound, J. D., Marr, L. A., Willems, J. J. L. P., Petrova, S., Ford, C. A., Paterson, M., Devitt, A. and Gregory, C. D. (2013) Innate recognition of apoptotic cells: novel apoptotic cell-associated molecular patterns (ACAMPs) revealed by cross-reactivity of anti-LPS antibodies. Cell Death & Differentiation. doi:10.1038/cdd.2012.165[Online]

  • Leslie, L., Marshall, L. J., Devitt, A., Hilton, A. & Tansley, G. (2012) Cell exclusion in Couette flow: evaluation through flow visualisation and mechanical forces.  Artificial Organs. In press.

  • Torr, E. E., Gardner, D. H., Thomas, L., Goodall, D. M., Bielemeier, A., Willetts, R., Griffiths, H. R., Marshall, L. J. and
    Devitt, A. (2011).
    Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.
    Cell Death & Differentiation. 

  • Henrikson-Lacey, M., Devitt, A. & Perrie, Y.P. (2011).
    The vesicle size of DDA:TDB liposomal adjuvants plays a role in the cell-mediated immune response but has no significant effect on antibody production
    Journal of Controlled Release.
      154: 131-137. [Online]
  • Devitt, A. & Marshall, L.J. (2011).
    The innate immune system and the clearance of apoptotic cells.
    Journal of Leukocyte Biology.  In press. [Online

  • Pamukcu, B., Lip, G. Y. H., Devitt, A., Griffiths, H. R. & Shantsila, E. (2010).
    The role of monocytes in atherosclerotic coronary artery disease.
    Annals of Medicine. 42(6): 394-403.

  • Shantsila, E, Devitt A. & Lip, G. Y. H. (2010).
    Circulating monocytes and atherogenesis: from animal experiments to human studies.
    Thrombosis and Hemostasis. 104(2): 191-193. [Online]

  • Gregory, C. D., Pound, J. D., Devitt, A., Wilson-Jones, M., Ray, P. and Murray, R. J. (2009).
    Inhibitory effects of persistent apoptotic cells on monoclonal antibody production in vitro: simple removal of non-viable cells improves antibody productivity by hybridoma cell culture.[Online]

  • Devitt, A., Parker, K., Clay, M. C., Hay, L. A., Bellamy, C. O., Lacey-Hulbert, A., Gangloff, S. C., Goyert, S. C. and Gregory, C. D. (2004).
    Persistence of apoptotic cells without autoimmune disease or inflammation in CD14-/- mice.
    Journal of Cell Biology.
    167(6): 1161-1170. [Online]

  • Gregory, C. D. & Devitt, A. (2004).
    The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically.
    . 113:1-14. [Online]

  • Henriksen, P.A., Devitt, A., Kotelevtsev, Y. and J-M Sallenave (2004).
    Gene delivery of the elastase inhibitor elafin protects macrophages from neutrophil elastase-mediated impairment of apoptotic cell recognition.
    FEBS Letters
    . 574:80-84. [Online]

  • Devitt, A., Pierce, S. E., Moffatt, O. D. and Gregory, C. D. (2003).
    CD14-dependent clearance of apoptotic cells by human macrophages: the role of phosphatidylserine.
    Cell Death & Differentiation
    10:371-382. [Online]

  • Turner, C., Devitt, A., Parker, K., MacFarlane, M., Giuliano, M., Cohen, G. and Gregory, C. D. (2003).
    Macrophage-mediated clearance of cells undergoing caspase-3-independent death.
    Cell Death & Differentiation.
    10:302-312. [Online]

  • Drewett, V., A. Devitt, J. Saxton, N. Portman, P. Greaney, N. Cheong, T. F. Alnemri, E. Alnemri, and P. E. Shaw. (2001).
    Serum Response Factor Cleavage by Caspases 3 and 7 Linked to Apoptosis in Human BJAB Cells
    J. Biol. Chem
    . 276:33444-33451. [Online]

  • Gregory, C. D. and Devitt, A. (1999)
    CD14 and apoptosis.
    , 4, 11-20. [Online]

  • Moffatt, O. D., Devitt, A., Bell, E. D., Simmons, D. L. and Gregory, C. D. (1999)
    Macrophage recognition of ICAM-3 on apoptotic leukocytes.
    Journal of Immunology
    , 162, 6800-6810. [Online]

  • Devitt, A., Moffatt, O. D., Raykundalia, C., Capra, J. D., Simmons, D. L., and Gregory, C. D. (1998)
    Human CD14 mediates recognition and phagocytosis of apoptotic cells.
    , 392, 505-509. [Online]

  • Gregory, C. D., Devitt, A. and Moffatt, O. (1998)
    Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages.
    Biochemical Society Transactions
    , 26, 644-649.

  • Flora, P. K., Devitt, A., Johnson, G. D., Milner, A. E., and Gregory, C. D. (1996)
    Bcl-2 delays macrophage engulfment of human B-cells induced to undergo apoptosis.
    European Journal Of Immunology
    26, 2243-2247. [Online]

  • Devitt, A., Lund, P. A., Morris, A. G., and Pearce, J. H. (1996)
    Induction of α/β-interferon and dependent nitric-oxide synthesis during Chlamydia trachomatis infection of McCoy cells in the absence of exogenous cytokine.
    Infection and Immunity
    64, 3951-3956. [Online]

  • Pearce, J.H., Gaston, H., Deane, K., Devitt, A., Harper, A. and Jecock, R. (1994)
    Persistent forms and persistence of Chlamydia.
    Trends in Microbiology
    , 2(7), 257-258.

  • Coles, A. M., Reynolds, D. J., Harper, A., Devitt, A., and Pearce, J. H. (1993)
    Low-nutrient induction of abnormal chlamydial development - a novel component of chlamydial pathogenesis. 
    FEMS Microbiology Letters
    106, 193-200.
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   Book Chapters

  • Devitt, A. & Gregory, C. D. (2008).
    Innate immune mechanisms in the resolution of inflammation.
    In: Progress in Inflammation Series. The resolution of Inflammation. pp39-56.  Eds: Rossi, A. & Sawatzky, D.; Birkhäuser Verlag AG. [Online]

  • Devitt, A. & Gregory, C. D. (2004).
    Measurement of apoptotic cell clearance in vitro.
    In: Methods in Molecular Biology282:207-22. [Online]

  • Gregory, C. D. & Devitt, A. (2003).
    Innate Immunity and Apoptosis: CD14 dependent clearance of apoptotic cells.  In: Apoptosis and Autoimmunity.  Pp 111-132.  Eds: Herrmann, M. & Kalden, J. R.  Wiley-VCH. [Online]

  • Devitt, A., Lund, P. A., and Pearce, J. H. (1994)
    Cytokine-independent induction of nitric oxide during the initiation of chlamydial infection.
    Proceedings of the Eight International Symposium on Human Chlamydial Infections, pp. 411-414.  

 A Devitt - staff page - research pic

Book Reviews

  • Devitt, A. (2009). 
    Inflammation Research. DOI : 10.1007/s00011-009-0151-2. [Online]

  • Devitt, A. (2009). 
    Inflammopharmacology. DOI : 10.1007/s10787-009-0024-x. [Online]

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  •  Devitt, A. (2010)
    Therapeutic Methods
    GB Patent Application: GB1016864.9

  • Gregory, C.D., Devitt, A. and Tennant, I. (2006)
    Assay Method.
    International Patent Application Number: PCT/GB2005/004405. 
    Publication Number: WO/2006/054068. [Online]

  • Gregory, C.D., Devitt, A. and Tennant, I. (2005)
    Improvements in Cell Culture Productivity.
    International Patent Application Number: PCT/GB2004/003399.
    Publication Number: WO/2005/014801. [Online]


Membership of Professional Bodies


 Dr Andrew Devitt / Aston University / last updated 25 August 2015

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