Lecturer in Pharmaceutics
School of Life & Health Sciences
Aston University, Aston Triangle
Birmingham, B4 7ET, UK
Chronic and Communicable Conditions
Aston Research Centre for Healthy Ageing (ARCHA)
Teaching Activity on the MPharm Programme
PH1404: Formulation and optimisation of medicines - liquid dosage forms
PH1408 (Module coordinator): Professional development
PH4701: Clinical pharmaceutics
Qualifications & Education
- 2011 - 2012 Postgraduate Certificate of Professional Practice (PGCPP) in Higher Education, Aston University, UK
- 2007 - 2010 PhD, School of Pharmacy, The University of Queensland, Australia (Supervisor: Dr. Harendra S. Parekh and Prof. Sean C. Smith)
- 2002 - 2005 MSc (Pharmacy), Shenyang Pharmaceutical University, China
- 1996 - 2000 BSc (Pharmacy), Shenyang Pharmaceutical University, China
- 2011 - date Lecturer in Pharmaceutics, Aston University, UK
- 2005 - 2007 Research scientist, Shenzhen Main Luck Pharmaceutical Inc., China
- 2000 - 2002 Engineer, Tianjin Huajin Pharmaceutical Company, China
Dr Ouyang has pioneered the integration of molecular modeling techniques and experimental approaches in the field of pharmaceutics - 'computational pharmaceutics' - to discover the fundamental principles of drug delivery at the molecular level and then develop novel drug delivery systems that advance healthcare. Computational pharmaceutics has great potential to shorten the time-consuming process of formulation development and decrease high cost of formulation development by reducing trial-and-error in the conventional experiments. "Today the computer is just as important a tool for chemists as the test tube." (Nobel Prize in Chemistry 2013)
Cyclodextrin formulation. Cyclodextrins are a family of cyclic oligosaccharides, which are widely used for the solubilization of poor-soluble drugs. Molecular modeling techniques are able to screen the optimal formulation.
Solid dispersion formulation. Solid dispersion refers to the dispersion of one or more drug molecules (usually poorly-soluble drugs) in the carriers at the solid state by different preparation methods (e.g. hot melt-extrusion method). Molecular modeling techniques are used to predict the long-term physical stability, and then screen the optimal formulation.
Non-viral gene delivery systems. The key to gene therapy is the development of safe,efficient and biocompatible non-viral vectors for gene delivery. Our novel simulation approaches are able to extend our understanding of key mechanistic aspects of gene-carrier complexation, thereby advancing the rational design of non-viral gene delivery systems.
Book editor of <Computational Pharmaceutics - the application of molecular modeling in drug delivery> (John Wiley & Sons Ltd, 2014);
Scientific advisor to the Editors of <Journal of Pharmaceutical Sciences>;
Guest editor of Special Issue "Gene Therapy" of <Pharmaceutics>;
Fellow of the Higher Education Academy;
Member of The Academy of Pharmaceutical Sciences (UK), Royal Society of Chemistry (RSC) and The Controlled Release Society (CRS);
Reviewer of French National Research Agency (ANR) and BBSRC (UK);
Reviewer of pharmaceutical journals of <Molecular Pharmaceutics>, <International Journal of Pharmaceutics>, <Journal of Pharmacy Pharmacology>, <Drug Development and Industrial Pharmacy>, <American Journal of Pharmaceutical Education>, <BMC Biotechnology>, <Pharmaceutics>, <Biomacromolecules> , <Journal of Biomaterial Application>, <Bioconjugate Chemistry>, <Chemical Communications>, <Colloids and Surface B Biointerfaces>, <International Journal of Molecular Sciences>, <Chemical Physics Letter>, <Journal of Liposome Research>, <Journal of Physical Chemistry Letter>, <Journal of Photochemistry and Photobiology B Biology> and <Drug Delivery>;
- A. ElShaer, D. Ouyang, P. Hanson and A. R. Mohammed, Preparation and evaluation of amino acid based salt forms of model zwitterionic drug ciprofloxacin. Journal of Pharmaceutics & Drug Delivery Research. 2013, 2, 1;
- L. Gan, J. Wang, M. Jiang, H. Bartlett, D. Ouyang, F. Eperjesi, J. Liu, Y. Gan, Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers. Drug Discovery Today. 2013, 18(5-6), 290-297;
D. Ouyang, Investigating the molecular structures of solid dispersions by molecular dynamics simulations with the simulated annealing method, Chem. Phys. Lett., 2012, 554, 177-184;
- H, Zhang, D. Ouyang, V. Murthy, Y. Wong, Y. Wong, Z. P. Xu and S. C. Smith, Hydrotalcite Intercalated siRNA: Computaional Characterization of the Interlayer Environment. Pharmaceutics, 2012, 4, 296-313;
D. Ouyang, H. Parekh and S.C. Smith, Investigating cationic vector-RNA complexation by all-atomic molecular dynamics simulation. CRS Newsletter, 2012, 29(3), 10–11.
- Y. Perrie, R. K. Badhana, D.J. Kirby, D. Lowry, A. R. Mohammed and D. Ouyang, The impact of ageing on the barriers to drug delivery. J. Control. Release, 2012, 161,389-398;
D. Ouyang, H.Zhang, H. Parekh and S.C. Smith, The Effect of pH on PAMAM Dendrimer-siRNA Complexation – Endosomal Considerations as Determined by Molecular Dynamics Simulation. Biophys. Chem., 2011, 158, 126–133;
D. Ouyang, H.Zhang, H. Parekh and S.C. Smith, Structure and Dynamics of multiple polymers-siRNA Complexation by Molecular Dynamics Study. J. Phys. Chem. B., 2010, 114, 9231–9237
D. Ouyang, H.Zhang, D.Herten, H. Parekh and S.C. Smith, Structure, Dynamics and Energetics of siRNA-Cationic Vector Complexation: A Molecular Dynamics Study. J. Phys. Chem. B., 2010, 114, 9220–9230.
D. Ouyang, H.Zhang, D.Herten, H. Parekh and S.C. Smith, “Flexibility of Short-Strand RNA in Aqueous Solution as Revealed by Molecular Dynamics Simulation: Are A-RNA and A’-RNA Distinct Conformational Structures?” Aust. J. Chem., 2009, 62, 1054-1061.
D. Ouyang, N. Shah, H. Zhang, S.C. Smith and H. Parekh, “Reducible Disulphide-Based Non-Viral Gene Delivery Systems”, Mini-Rev. Med. Chem., 2009, 9, 1242-1250.
Invited lectures and oral presentations
- Computational Pharmaceutics - Virtual screening in formulation development. NanoFormulation 2013. (Manchester, UK, June 18-21, 2013).
- Computational pharmaceutics. Formulated Products-Meeting the Product and Process Design Challenge' Competition Briefing Event. (London, UK, May 1, 2013).
- Computational pharmaceutics. Nutrition for Life Birmingham Workshop. (Birmingham, UK, April 10, 2013).
- Computational Pharmaceutics - How to Apply Molecular Dynamics Simulation in Drug Delivery. School of Chemical Engineering, University of Birmingham. (Birmingham, UK, December 13, 2012).
- Computational pharmaceutics - the application of molecular modeling in drug delivery. 5th Midlands Biophysics Network Symposium. (Birmingham, UK, April 18, 2012).
- Computational pharmaceutics. Aston Research Centre for Healthy Ageing (ARCHA) seminar. (Aston University, UK, December 7, 2011).
- The Effect of pH on PAMAM Dendrimer-siRNA Complexation – Endosomal Considerations as Determined by Molecular Dynamics Simulation. 7th Annual Conference of the ARC Centre of Excellence for Functional Nanomaterials (ARCCFN). (Gold Coast, Queensland, Australia, November 25-26, 2010).
- Structure, Dynamics and Energetics of siRNA-polymer Complexation: A Molecular Dynamics Study. 6th Annual Conference of the ARC Centre of Excellence for Functional Nanomaterials (ARCCFN). (Coffs Harbor, New South Wales, Australia, November 9-11, 2009).