School of Life and Health sciences
Tel: +44 (0) 1212044022
Clinical and Systems Neuroscience
Aston Research Centre for Healthy Ageing (ARCHA)
- Present Postdoctoral research Fellow, ARCHA, Aston University
- 2007-2010 Postdoctoral research fellow, Aston University
- 2005-2007 Postdoctoral research fellow, Aston University
- 2001-2004 PhD Aston University
- 2000 Assistant forensic scientist, Forensic science service, Birmingham
- 1997-2001 BSc. Hons. Applied and Human biology (2:1), Aston University
Amyloid beta (Aβ) is a peptide present in brain cells and plays an important role in Alzheimer’s disease (AD). Due to an imbalance in the production and clearance of Aβ peptides they accumulate in the brain activating the immune system as well as blocking brain cellular communication. As a result brain cells begin to die causing loss of memory and dementia. The design of new human-based models will help us understand these processes, thus accelerating the design of successful treatments and we hope in the future to prevent the development of AD altogether.
We are currently using stem cells to produce brain cells in order to examine how changes in Aβ lead to AD. These cells can be grown to form the many cell types present in the brain. We are able to study the effects of Aβ on these different cell types when it starts to accumulate including those of the immune system. We are also investigating how Aβ affects brain cell communication. Creating a stem cell line that overproduces Aβ when they become neurons will allow scientists to study how these neurons sicken and die and to search for ways to slow or stop the disease.
A versatile in vitro human model of aspects of Alzheimer’s Disease. Marta Tarczyluk (ARCHA PhD Studentship).
Versatile in vitro stem cell model of Alzheimer’s disease. Alzheimer’s research trust Pilot project.
Financial support from, Alzheimer’s Research trust, Humane research trust, and Antidote Europe are gratefully acknowleged.
In vitro toxicology society poster prize winner
Member of the Midlands ART Network, funded by the Alzheimer’s Research Trust.
In Vitro Toxicology society
- Woehrling EK, Hill EJ, Coleman MD, Evaluation of the suitability of human neuronal and astrocytic cell systems for in vitro preliminary neurotoxicity screening, Neurotoxicity Research, 2009 (DOI 10.1007/s12640-009-9084-3).
- Hill EJ, Vernallis AB, Polarized secretion of Leukemia Inhibitory Factor. BMC Cell Biology, 2008.
- Hill EJ, Woehrling EK, Prince M, and Coleman MD. Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology, 2008.
- Woerhrling E.K, Hill E.J, Coleman M.D. Development of a neurotoxicity test system using human post-mitotic astrocyte and neuronal cell lines in co-culture. Toxicology in-Vitro, 2007