Cellular pathology

Key information

Duration: Duration times vary. Use the contact details below to enquire about this.

Location: Aston University, Birmingham

Fee: £550 per delegate

To register: Please complete this online application form.The Biomedical Science top-up modules are for people who have a science degree but wish to pursue a career as a Biomedical Scientist. Prior to registering for any top-up modules you need to contact the Institute of Biomedical Science for advice about which modules you require:

Telephone: + 44 (0)20 7713 0214 or email: mail@ibms.org

Further information: Contact LHS Admissions lhs_admissions@aston.ac.uk or telephone 0121 204 3000

Aims of the module

This module aims to provide students with a comprehensive overview of the key concepts, techniques and current laboratory practice used in cellular pathology (histopathology and cytopathology). The module will allow students to develop an understanding of the role this biomedical science discipline plays in the diagnosis, assessment and treatment of disease.

Module content

The module will comprise the following content:
  • Cellular pathology laboratory organisation and management – remit of histopathology and cytopathology, function within the National Health Service (NHS) and relationships with other health professions, health and safety, standard operating procedures (SOP), internal quality control, external quality assurance (EQA), Clinical Pathology Accreditation (CPA), reporting, telepathology, audit, tissue retention / material archiving and legislation
  • Collection and processing of tissue samples – types of histological specimen (biopsy, excision, resection), laser cell capture and micro-dissection, fixation and fixatives, specimen dissection and sampling, tissue processing (paraffin wax, resin, plastic, celloidin), microtomy and cryotechniques
  • Exfoliative Cytopathology – gynaecological and non-gynaecological specimens, range of cytological sampling and preparative techniques, liquid based cytology (LBC), national cervical screening programme in the United Kingdom, cell culture and flow cytometry, applications of exfoliative cytology in the diagnosis of disease
  • Staining theory and the diagnostic relevance of tinctorial staining techniques in the modern laboratory – Haematoxylin and Eosin (H&E), connective tissues (trichrome staining), mucins, proteins and nucleic acids, pigments and minerals and infective agents
  • Immunocytochemistry – monoclonal and polyclonal antibodies, antigen retrieval techniques, immunocytochemical technique, improvement of selectivity and sensitivity, use of antibody panels in diagnosis (breast disease, skin disease, lymphoma, prostate disease, tumour markers in secondary disease)
  • Applications of microscopy in the investigation of disease – brightfield, fluorescence, polarising phase contrast, darkground, confocal, electron (transmission and scanning) and photomicroscopy
  • Aspects of molecular biology with applications in cellular pathology i.e. in-situ / fluorescence in-situ hybridisation (FISH), polymerase chain reaction (PCR), tissue micro-arrays
  • Structure and function of normal cells and tissues and the effects of disease processes upon them – inflammation, carcinogenesis, haematological disorders, infection, autoimmunity, neurological disease and endocrine disorders