I am currently a research fellow with the multidisciplinary Biomaterials Research Unit (BRU). My research focuses on biomaterial/host interaction studies and biocompatibility testing of existing and new biomaterials including the assessment of soft contact lenses, wound dressings and an array of new hydrogel based polymers. This post followed on from my PhD with BRU which was entitled ‘Immunological and biochemical techniques in the analysis of tear proteins’.
Prior to my PhD I took a post as a Clinical Scientist in tissue typing with the National Blood Service. In 1992 I worked in a rheumatic diseases diagnostic laboratory based in Birmingham University in conjunction with the Binding Site Ltd, as part of my MSc in Immunology. I gained my first degree in Microbiology from the University College Galway in Ireland (now NUIG) in 1991.
Qualifications & Education
- BSc Microbiology, University College Galway, Ireland -1991
- MSc, Immunology Birmingham University - 1992
- PhD, Aston University, 1998
During my time at Aston University I have developed expertise in a wide range of aspects of immunological, biochemical and cell culture techniques in the characterisation of novel biomaterials, in addition to tear and wound fluid analysis. My work has focused on the identification of key immunoregulatory markers in the ocular environment in response to, the insertion and wear of, a variety hydrogel contact lens materials. I am currently interested in the determination of individual tear protein profiles by lab-a-on-chip protein sizing separation microfluidics, which can monitor the ever changing tear specifically in relation to affects of contact lens wear and ocular dysfunction on the normal tear chemistry.
Membership of Professional Bodies
- British Contact Lens Association
- Mann A, Gupta N, Heitmar R, Patel S, Tighe B. Seasonal allergic conjunctivitis tears:protein fingerprint analysis. Contact Lens and Anterior Eye 2008;31:319.
- Mann AM, Tighe BJ. Tear analysis and lens–tear interactions: Part I. Protein fingerprinting with microfluidic technology. Contact Lens and Anterior Eye 2007;30:163-173.
- Bateman S, Mann A, Tighe BJ. Towards the development of purpose-designed ocular bandage lenses. Acta Ophthalmologica Scandinavica 2006;84:39&155..
- Mann AM, Tighe BJ. Presence of IgE antibody and kinin components in atopic and non-atopic contact lens wearing patients. Ophthalmic Res 2005;37:25 & 139.
- Mann A, Santodomingo-Rubido J, Peach H, Franklin V, Wolffsohn J, Tighe BJ. Continuous and daily silicone hydrogel contact lens wear: biochemical markers. Ophthalmic. Res, 2003;35:16
- Mann A, Jones L, Tighe, BJ. The application of counter immunoelectrophoresis in ocular protein studies: Pt. I. Time dependent deposition patterns of immunoregulatory proteins on anionic contact lenses. CLAE 2002;25:73-80.
- Mann A, Tighe B. The application of counter immunoelectrophoresis in ocular protein studies: Pt. II: Kinin activity in the lens-wearing eye. CLAE 2002;25:81-88.
- Tighe BJ, Franklin VJ, Graham C, Mann A, Guillon M. Vitronectin Adsorption on contact lens surfaces during wear: Locus and significance. Adv Exp Med Biol 1998;438:769-773.