The MAPK cascades are evolutionary conserved signalling pathways that play a significant role in many cellular processes, including proliferation, differentiation, apoptosis, learning and memory, and angiogenesis. My research is focussed on the mechanisms that determine the specificity of cellular signalling in order to ensure that the outcome of the process accurately reflects the incoming signals received by the cell in a specific environment. This includes investigations into the regulation of signalling dynamics, particularly regarding those mechanisms that confer temporal and spatial control over the MAPK pathways. I am also interested in elucidating the crosstalk between different signal transduction pathways and their contribution to signal modulation. Finally, I am investigating the re-programming of cellular signalling pathways in disease processes and the role of this plasticity in drug resistance.
A recent area of my research has been the role of the ERK5 MAPK pathway in angiogenic processes. Both impaired as well as excessive growth of blood vessels contribute to a number of diseases and influence the efficacy of drug treatment. The main aims of this research are to investigate the molecular mechanisms by which the ERK5 MAPK pathway maintains the health of endothelial tissues. Advances in our understanding of angiogenic processes resulting from this research will help to develop better cardio-protective strategies and advanced therapies for a number of cardiovascular-related diseases.
Current PhD Students:
Mr Ahmed Alasseri
Project Title: ERK5 Signalling in Angiogenesis