Dr Murdoch joined the Vascular Medicine Section within Aston Medical School in October 2013 and was awarded a Marie Skłodowska-Curie International Incoming Fellowship to disseminate cardiovascular in vivo techniques and Redox vascular pathophysiology to Aston University and the wider EU community.
Previously he spent 3-years in the US working with Richard Cohen and Reiko Matsui at the Whitaker Cardiovascular Unit, School of Medicine Boston University investigating the role of redox signalling in neovascularisation.
Dr Murdoch’s post-doctoral research and Ph.D took place in the BHF Centre of Excellence at King’s College London under the supervision of the talented Prof Ajay Shah. Where he investigated oxidative stress signalling in left ventricular hypertrophy, diastolic dysfunction and hypertension.
Before he undertook a Ph.D Dr Murdoch spent five-years working in industry for Pharmagene (now Asterand) as a Scientist in the Functional Pharmacology department where among other roles he was an integral member of a team which developed a potential migraine treatment which discovered a novel therapeutic mechanism and drug in Phase Two clinical trials. His initial contact with Pharmagene was through an Industrial Placement as part of an undergraduate course Pharmacology with Industrial Experience at the University of Edinburgh.
2004 -2009 - British Heart Foundation Ph.D student. King’s College London, UK. Research Project: Influence of endothelial redox state on cardiac remodelling in response to chronic pressure overload.
1996 – 2000 - Undergraduate Pharmacology with Honors and Industrial Placement University of Edinburgh, UK.
2014 - Marie Curie International Fellow
School of Medicine. Boston University, MA.
2009 -2011 - Post-Doctoral Fellow. Cardiovascular Division, BHF Centre of Excellence, King’s College London, UK.
2004 -2009 - British Heart Foundation Ph.D student. King’s College London, UK. Research Project: Influence of endothelial redox state on cardiac remodeling in response to chronic pressure overload.
2000 -2004 - Scientist, Asterand PLC. Royston UK.
I am interested in how redox signaling affects cardiovascular pathophysiology. In particular my research has concentrated on signaling in the endothelial and inflammatory cell and the implication on cardiovascular function in vivo. I am currently investigating a number of targets in pre-eclampsia using a wide range of clinical samples, murine models and in vitro studies. One aspect is to investigate during pre-eclampsia whether signaling is affected by the S- glutathionylation, a post-translation modification which occurs during oxidative stress.
My previous research in Boston was to identify how angiogenesis can be regulated by S- glutathionylation. In Kings College London I investigated the cell specific role of isoforms of the NADPH oxidase enzymes, Nox2 and Nox4 in the endothelium on left ventricular hypertrophy and hypertension. I successfully modeled a human disease in a mouse, measured cardiovascular parameters and subsequently conducted biochemical and molecular assays in order to identify novel molecular mechanisms.
I have spent time working in industry where I helped find novel targets for disease and tested possible drug candidates.
Undergraduate Placement Students